906371-80-0

Upstream product

• 6298-19-7 2-chloro-3-aminopyridine 
• 459-57-4 4-fluorobenzaldehyde 

Downstream Products

• 142872-80-8 1-(4-fluorobenzyl)-1H-imidazo[4,5-b]pyridine 
• 1431659-82-3 4-(1-(4-fluorobenzyl)-1H-imidazo[4,5-b]pyridin-2-yl)morpholine 
• 1431659-64-1 2-chloro-1-(4-fluorobenzyl)-1H-imidazo[4,5-b]pyridine 
• 906532-73-8 1-(2-chloro-pyridin-3-yl)-1-(4-fluoro-benzyl)urea 

Relevant academic research and scientific papers

Substituted benzimidazoles as modulators of Ras signaling

Benzimidazole compounds that increase the rate of SOS-mediated nucleotide exchange on Ras by binding to a functionally relevant, chemically tractable pocket on the SOS protein, as part of the Ras:SOS:Ras complex.

Efficient access to azaindoles and indoles

An expedient, catalytic method for the synthesis of diverse azaindoles and indoles, starting from readily available and inexpensive starting materials, is described. Conditions were developed for effective reductive alkylation of electron-deficient o-chlo

Efficient access to cyclic ureas via Pd-catalyzed cyclization

An efficient regioselective method for the preparation of structurally diverse imidazopyridinones and benzoimidazolones starting from readily available and economical starting materials is described. High-yielding reductive alkylation of electron-deficient o-haloarylamines followed by treatment with inexpensive N-chlorosulfonyl isocyanate afforded primary ureas in good overall yields. A Pd-catalyzed urea cyclization reaction furnished imidazopyridinones and benzoimidazolones in excellent yields. Overall, the developed chemistry provides rapid access to pharmaceutically important heterocyclic compounds with high efficiency.