142874-60-0

Upstream product

• 611-70-1 phenyl isopropyl ketone 
• 103323-59-7 2-methoxy-3,4,6-trimethylbromobenzene 
• 1195-98-8 2-methyl-2-phenylpropionitrile 
• 3805-10-5 2,2-(dimethyl)-2-phenylacetaldehyde 
• 697-82-5 2,3,5-trimethylphenol 
• 142874-47-3 1-(2-Methoxy-3,4,6-trimethylphenyl)-1-phenyl-2-methylpropanol 

Downstream Products

• 142874-69-9 2,2,4,6,7-Pentamethyl-5-nitro-3-phenyl-2,3-dihydrobenzofuran 
• 142873-25-4 2,2,4,6,7-pentamethyl-3-phenyl-2,3-dihydro-1-benzofuran-5-amine 

Relevant academic research and scientific papers

PROCESS FOR PRODUCING BENZOFURAN DERIVATIVE

A novel process for efficiently and easily producing a compound represented by the formula: wherein ring A is a benzene ring that may be optionally further substituted in addition to the group represented by W, or a salt thereof; which comprises reacting a compound represented by the formula: wherein R1 and R2 are the same or different and each is a hydrogen atom, an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, Y is a halogen atom, ring A is a benzene ring that may be optionally further substituted in addition to the group represented by Y and ring B is an optionally substituted benzene ring, or a salt thereof, with a compound represented by the formula:WH wherein W is or wherein ring C is an optionally substituted benzene ring, ring D is an optionally substituted 5- to 7-membered nitrogen-containing heterocyclic ring, R3 is a hydrogen atom, an aliphatic hydrocarbon group containing an aromatic group or an acyl group, and R4 is a hydrogen atom, an optionally substituted hydrocarbon group or an acyl group, or a salt thereof and thereafter, if necessary, deprotecting the resultant product, which is suitable for industrial production.

A convenient ring formation of 3-aryl-2,2-dialkyl-2,3-dihydrobenzofurans from phenols and 2-aryl-2,2-dialkylacetaldehydes

A new and simple route for the preparation of 3-aryl-2,2-dialkyl-2,3- dihydrobenzofurans from phenols is described. In the presence of an acid catalyst phenols react with 2-aryl-2,2-dialkylacetaldehydes, prepared in good yield from 2-arylacetonitriles in 2 steps, to give 3-aryl-2,2-dialkyl-2,3- dihydrobenzofurans. Electron-donating substituents were required on the phenols in order to give 3-aryl-2,2-dialkyl-2,3-dihydrobenzofurans in good yield.

5-Aminocoumarans: Dual inhibitors of lipid peroxidation and dopamine release with protective effects against central nervous system trauma and ischemia

A series of 2,3-dihydro-5-benzofuranamines (5-aminocoumarans) were developed for the treatment of traumatic and ischemic central nervous system (CNS) injury. Compounds within this class were extremely effective inhibitors of lipid peroxidation in vitro an

Aminocoumaran derivatives, their production and use

A novel aminocoumaran derivatives of the general formula (I): STR1 wherein R1 and R2 are a hydrogen atom, an acyl group, an alkoxycarbonyl group, an aliphatic group or aromatic group; R3 R4 and R5 are an optionally acylated hydroxyl optionally substituted amino group, alkoxy group or aliphatic group, or two of R3, R4 and R5 may be linked together to form a carbocyclic group; R6 and R7 are an aliphatic group and at least one of them has a methylene group at the α-position; R8 and R9 are a hydrogen atom or an aliphatic group or aromatic group, or a salt thereof is useful for medicines for preventing and treating various diseases such as arterial schleosis, hepatopathy, cerebrovascular diseases and the like.