1428858-65-4

Basic information

• Product Name: N-(quinolin-8-yl)-[1,1′-biphenyl]-3-carboxamide
• Synonyms: N-(quinolin-8-yl)-[1,1′-biphenyl]-3-carboxamide
• CAS NO: 1428858-65-4
• Molecular Weight: 324.382
• Mol File: 1428858-65-4.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: N-(quinolin-8-yl)-[1,1′-biphenyl]-3-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(quinolin-8-yl)-[1,1′-biphenyl]-3-carboxamide(1428858-65-4)
• EPA Substance Registry System: N-(quinolin-8-yl)-[1,1′-biphenyl]-3-carboxamide(1428858-65-4)

Safety Data

• Hazardous Substances Data: 1428858-65-4(Hazardous Substances Data)

Upstream product

• 899677-43-1 3-bromo-1-(quinolin-8-yl)benzamide 
• 585-76-2 m-bromobenzoic acid 
• 98-80-6 phenylboronic acid 
• 578-66-5 8-amino quinoline 
• 716-76-7 3-phenylbenzoic acid 
• 42498-44-2 3-phenylbenzoyl chloride 

Downstream Products

• 1428858-81-4 4-butyl-N-(quinolin-8-yl)-[1,1'-biphenyl]-3-carboxamide 
• 1436849-47-6 C₂₈H₂₁N₃O 
• 1436849-46-5 C₃₀H₂₁N₃O 
• 1436849-45-4 C₃₂H₂₂N₂O 
• 1436849-44-3 C₃₂H₂₂N₂O 
• 1436849-43-2 C₂₉H₂₂N₂O₂ 
• 1436849-42-1 C₂₉H₂₂N₂O 
• 1436849-41-0 C₃₀H₂₂N₂O₂ 
• 1436849-40-9 C₂₉H₁₉F₃N₂O 
• 1436849-39-6 C₃₀H₂₂N₂O₃ 

Relevant articles and documents

Copper-Catalyzed Selective ortho-C-H/N-H Annulation of Benzamides with Arynes: Synthesis of Phenanthridinone Alkaloids

An efficient and convenient copper-catalyzed method has been developed to achieve direct ortho-C-H/N-H annulation to synthesize phenanthridinones with arynes. This method highlights an emerging strategy to transform inert C-H bonds into versatile functional groups in organic synthesis and provides a new way to synthesize phenanthridinone alkaloids efficiently.

Facile Synthesis of Alkylidene Phthalides by Rhodium-Catalyzed Domino C?H Acylation/Annulation of Benzamides with Aliphatic Carboxylic Acids

The Rh-catalyzed ortho-C(sp2)?H functionalization of 8-aminoquinoline-derived benzamides with aliphatic acyl fluorides generated in situ from the corresponding acids has been developed. This reaction initiated with 8-aminoquinoline-directed ortho-C(sp2)?H acylation, which was accompanied by subsequent intramolecular nucleophilic acyl substitution of amide group to produce alkylidene phthalides This approach exhibits high stereo-selectivity for Z-isomer products, and tolerates a variety of functional groups as well as aliphatic carboxylic acids with diverse structural scaffolds.

Chelation-Assisted Nickel-Catalyzed Oxidative Annulation via Double C-H Activation/Alkyne Insertion Reaction

A nickel/NHC system for regioselective oxidative annulation by double C-H bond activation and concomitant alkyne insertion is described. The catalytic reaction requires a bidentate directing group, such as an 8-aminoquinoline, embedded in the substrate. Various 5,6,7,8-tetrasubstituted-N-(quinolin-8-yl)-1-naphthamides can be prepared as well as phenanthrene and benzo[h]quinoline amide derivatives. Diarylalkynes, dialkylalkynes, and arylalkylalkynes can be used in the system. A Ni0/NiII catalytic cycle is proposed as the main catalytic cycle. The alkyne plays a double role as a two-component coupling partner and as a hydrogen acceptor. In two shakes: Oxidative annulation by a double C-H activation/alkyne insertion reaction was achieved by a nickel/NHC system. A Ni0/NiII catalytic cycle is proposed as the main catalytic cycle. The alkyne plays a double role as a two-component coupling partner and as a hydrogen acceptor.