1428858-80-3Relevant academic research and scientific papers
The nickel(II)-catalyzed direct benzylation, allylation, alkylation, and methylation of C-H bonds in aromatic amides containing an 8-aminoquinoline moiety as the directing group
Aihara, Yoshinori,Wuelbern, Jendrik,Chatani, Naoto
supporting information, p. 438 - 446 (2015/03/31)
Direct alkylation via the cleavage of the ortho C-H bonds by a nickel-catalyzed reaction of aromatic amides containing an 8-aminoquinoline moiety as the directing group with alkyl halides is reported. Various alkyl halides, including benzyl, allyl, alkyl,
Iron-catalyzed C(sp2)-H alkylation of carboxamides with primary electrophiles
Monks, Brendan M.,Fruchey, Erin R.,Cook, Silas P.
supporting information, p. 11065 - 11069 (2015/03/30)
The direct ortho alkylation of 8-aminoquinoline-based aryl amides was achieved with primary alkyl bromides in high yields in the presence of an iron catalyst 1,2-bis(diphenylphosphino)ethane (dppe) and PhMgBr in 2-MeTHF.
Nickel-catalyzed direct alkylation of C-H bonds in benzamides and acrylamides with functionalized alkyl halides via bidentate-chelation assistance
Aihara, Yoshinori,Chatani, Naoto
, p. 5308 - 5311 (2013/05/21)
The alkylation of the ortho C-H bonds in benzamides and acrylamides containing an 8-aminoquinoline moiety as a bidentate directing group with unactivated alkyl halides using nickel complexes as catalysts is described. The reaction shows high functional group compatibility. In reactions of meta-substituted aromatic amides, the reaction proceeds in a highly selective manner at the less hindered C-H bond.
