1428897-15-7Relevant articles and documents
Ligand modifications modulate the mechanism of binuclear phosphatase biomimetics
Dalle, Kristian E.,Daumann, Lena J.,Schenk, Gerhard,McGeary, Ross P.,Hanton, Lyall R.,Gahan, Lawrence R.
, p. 1336 - 1343 (2013)
Complexation of dimethyl-6,6′-(2-hydroxy-5-methyl-1,3-phenylene) bis(methylene)bis((2-hydroxyethyl)azanediyl)bis(methylene)dipicolinate (Me 2H3L4) and 2,2′-(2-hydroxy-5-methyl-1,3-phenylene) bis(methylene)bis(((6-methylpyridin-2-yl)methyl)azanediyl)diethanol (H 3L5) with Zn(II) afforded the complexes [Zn2(H 2L4)(H2O)2](ClO4) and [Zn 2(H2L5)(CH3CO2)(H 2O)](PF6)2·2H2O, which were characterized by 1H and 13C NMR spectroscopy, mass spectrometry, microanalysis, and the former by X-ray crystallography. Functional studies of the zinc complexes with the substrate bis(2,4-dinitrophenyl) phosphate (BDNPP) showed the complexes to be competent catalysts with k cat = 3.52 ± 0.03 × 10-4 and 1.27 ± 0.04 × 10-3 s-1 (Km = 6.7 ± 0.9; 13.8 ± 1.5 mM), with catalytically relevant pKas of 9.4 and 6.6, respectively. The pKa values are discussed with respect to the potential nucleophilic species and the effect of the donor environment.
