1428900-30-4

Basic information

• Product Name: 2-{3-[3-(4-fluorophenoxy)-5-{[(4-hydroxy-4-isobutyl-1-piperidinyl)carbonyl]amino}phenoxy]phenyl}-2-methylpropanoic acid
• CAS NO: 1428900-30-4
• Molecular Weight: 564.654
• Mol File: 1428900-30-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-{3-[3-(4-fluorophenoxy)-5-{[(4-hydroxy-4-isobutyl-1-piperidinyl)carbonyl]amino}phenoxy]phenyl}-2-methylpropanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-{3-[3-(4-fluorophenoxy)-5-{[(4-hydroxy-4-isobutyl-1-piperidinyl)carbonyl]amino}phenoxy]phenyl}-2-methylpropanoic acid(1428900-30-4)
• EPA Substance Registry System: 2-{3-[3-(4-fluorophenoxy)-5-{[(4-hydroxy-4-isobutyl-1-piperidinyl)carbonyl]amino}phenoxy]phenyl}-2-methylpropanoic acid(1428900-30-4)

Safety Data

• Hazardous Substances Data: 1428900-30-4(Hazardous Substances Data)

Upstream product

• 2265-94-3 1,3-difluoro-5-nitrobenzene 
• 149490-75-5 2-(3-hydroxy-phenyl)-2-methyl-propionic acid methyl ester 

Relevant articles and documents

Discovery of novel S1P2 antagonists, part 3: Improving the oral bioavailability of a series of 1,3-bis(aryloxy)benzene derivatives

The structure of the S1P2 antagonist 1 has been modified with the aim of improving its oral bioavailability. The chemical modification of the alkyl chain and carboxylic acid moieties of 1 led to significant improvements in the oral exposure of compounds belonging to this series. The optimization of the ring size of the urea portion of these molecules also led to remarkable improvements in the oral exposure. Based on these changes, the pyrrolidine derivative 16 was identified as a suitable candidate compound and showed excellent pharmacokinetic profiles in rat and dog, while maintaining high levels of potency and selective antagonistic activity toward S1P2.