1428901-42-1

Basic information

• Product Name: 4-bromo-3-methyl-5-(2-nitrophenyl)-3-phenyl-3H-pyrazole
• Synonyms: 4-bromo-3-methyl-5-(2-nitrophenyl)-3-phenyl-3H-pyrazole
• CAS NO: 1428901-42-1
• Molecular Weight: 358.194
• Mol File: 1428901-42-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-bromo-3-methyl-5-(2-nitrophenyl)-3-phenyl-3H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-bromo-3-methyl-5-(2-nitrophenyl)-3-phenyl-3H-pyrazole(1428901-42-1)
• EPA Substance Registry System: 4-bromo-3-methyl-5-(2-nitrophenyl)-3-phenyl-3H-pyrazole(1428901-42-1)

Safety Data

• Hazardous Substances Data: 1428901-42-1(Hazardous Substances Data)

Upstream product

• 552-89-6 2-nitro-benzaldehyde 
• 98-86-2 acetophenone 
• 4545-21-5 acetophenone p-toluenesulfonylhydrazone 
• 253684-24-1 1-(2,2-dibromovinyl)-2-nitrobenzene 

Relevant articles and documents

An efficient one-pot synthesis of 3,5-diaryl-4-bromopyrazoles by 1,3-dipolar cycloaddition of in situ generated diazo compounds and 1-bromoalk-1-ynes

A simple, highly efficient, one-pot synthesis of 3,5-di-aryl-4- bromopyrazoles via 1,3-dipolar cycloaddition of diazo compounds and alkynyl bromides has been developed. The diazo compounds and alkynyl bromides were generated in situ from tosylhydrazones and gem-dibromoalkenes, respectively. When ketone-derived hydrazones were used, 3,5-diaryl-4-bromo-3H-pyrazoles were obtained and the isomerization products 3,5-diaryl-4-bromo-1H-pyrazoles were formed when using aldehyde-derived hydrazones. The reaction system exhibited high regioselectivity and good functional group tolerance. Both electron-rich and electron-deficient-substituents on the aromatic ring of the hydrazones or the gem-dibromoalkenes gave desired products in moderate to good yields (67-86%). Georg Thieme Verlag Stuttgart - New York.