1428932-01-7Relevant academic research and scientific papers
α-Palladation of imines as entry to dehydrogenative heck reaction: Aerobic oxidative cyclization of N-allylimines to pyrroles
Chen, Zhiyuan,Lu, Beili,Ding, Zhenhua,Gao, Ke,Yoshikai, Naohiko
supporting information, p. 1966 - 1969 (2013/06/04)
We report here a palladium(II)-catalyzed oxidative cyclization reaction of N-allylimines derived from methyl ketones, typically acetophenones, affording pyrrole derivatives at room temperature under oxygen atmosphere. The reaction likely proceeds through α-palladation of the imine followed by olefin migratory insertion and β-hydride elimination, thus representing a new example of aerobic dehydrogenative Heck cyclization.
