1429035-14-2Relevant academic research and scientific papers
Asymmetric Michael/aromatization reaction of azlactones to α,β-unsaturated pyrazolones with C-4 regioselectivity catalyzed by an isosteviol-derived thiourea organocatalyst
Geng, Zhi-Cong,Chen, Xiang,Zhang, Jin-Xin,Li, Ning,Chen, Jian,Huang, Xiao-Fei,Zhang, Shao-Yun,Tao, Jing-Chao,Wang, Xing-Wang
, p. 4738 - 4743 (2013)
Pyrazoles are an important class of molecular structures with significant biological and pharmaceutical activities. Herein, heterocyclic compounds containing both a pyrazole motif and a masked amino acid structure are synthesized through the asymmetric Michael/aromatization of azlactones to α,β-unsaturated pyrazolones by using isosteviol-derived amine thiourea as the organocatalyst. The products are obtained in good yields (up to 93 %) with good diastereoselectivities and good enantioselectivities (up to >10:1 dr, 97 % ee). Copyright
