23901-60-2

Basic information

• Product Name: (4Z)-5-methyl-2-phenyl-4-(phenylmethylidene)-2,4-dihydro-3H-pyrazol-3-one
• Synonyms: 3H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2-phenyl-4-(phenylmethylene)-, (4Z)-
• CAS NO: 23901-60-2
• Molecular Formula: C₁₇H₁₄N₂O
• Molecular Weight: 262.3059
• Mol File: 23901-60-2.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 404.4°C at 760 mmHg
• Flash Point: 198.4°C
• Density: 1.12g/cm³
• Vapor Pressure: 9.48E-07mmHg at 25°C
• Refractive Index: 1.612
• CAS DataBase Reference: (4Z)-5-methyl-2-phenyl-4-(phenylmethylidene)-2,4-dihydro-3H-pyrazol-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: (4Z)-5-methyl-2-phenyl-4-(phenylmethylidene)-2,4-dihydro-3H-pyrazol-3-one(23901-60-2)
• EPA Substance Registry System: (4Z)-5-methyl-2-phenyl-4-(phenylmethylidene)-2,4-dihydro-3H-pyrazol-3-one(23901-60-2)

Safety Data

• Hazardous Substances Data: 23901-60-2(Hazardous Substances Data)

Usage

General Description

(4Z)-5-methyl-2-phenyl-4-(phenylmethylidene)-2,4-dihydro-3H-pyrazol-3-one, also known as 4Z-5-methyl-2-phenyl-4-benzylidene-2,4-dihydro-3H-pyrazol-3-one, is a chemical compound with a molecular formula of C15H14N2O. It is a pyrazolone derivative and has a 3H-pyrazol-3-one core structure with a phenylmethylidene side chain and a methyl substitution at the 5-position. (4Z)-5-methyl-2-phenyl-4-(phenylmethylidene)-2,4-dihydro-3H-pyrazol-3-one has potential pharmaceutical applications due to its biological activities, including anti-inflammatory, analgesic, and antioxidant properties. It may also have potential as a starting material for the synthesis of other organic compounds. However, further research and studies are needed to fully understand and utilize its potential uses and applications.

Upstream product

• 19735-89-8 3-methyl-1-phenylpyrazolin-5(4H)-one 
• 100-52-7 benzaldehyde 
• 89-25-8 edaravone 
• 538-51-2 benzylidene phenylamine 
• 942-32-5 5-methyl-2-phenyl-2H-pyrazol-3-ol 
• 110-89-4 piperidine 
• 100-51-6 benzyl alcohol 
• 100-63-0 phenylhydrazine 
• 3381-47-3 N-benzylidene-4-iodoaniline 
• 57303-46-5 4,4'-(phenylmethylene)bis(3-methyl-1-phenyl-pyrazol-5-ol) 
• 76086-78-7 1-phenyl-3-methyl-4-<(4-iodophenylamino)phenyl>methyl-5-pyrazolone 
• 64-17-5 ethanol 
• 397878-11-4 5,5'-dimethyl-2,2'-diphenyl-1,2,1',2'-tetrahydro-4,4'-benzylidene-bis-pyrazol-3-one 

Downstream Products

• 57303-46-5 4,4'-(phenylmethylene)bis(3-methyl-1-phenyl-pyrazol-5-ol) 
• 1228302-06-4 5-(benzo[d]thiazol-2-yl)-1,4-dihydro-3-methyl-1,4-diphenylpyrano[2,3-c]pyrazol-6-amine 
• 1262111-43-2 C₂₃H₂₁N₃OS 
• 883-93-2 2-Phenylbenzothiazole 
• 1404553-96-3 3-((5R,8S,9R)-1-methyl-4-oxo-3,9-diphenyl-6-thioxo-2,3,7-triazaspiro[4.4]non-1-enecarbonyl)oxazolidin-2-one 
• 1404554-40-0 C₂₅H₂₄N₄O₄S 
• 1404554-41-1 C₂₁H₁₉N₃O₃S 
• 1418030-34-8 6-(4-bromophenyl)-4-methyl-2,10-diphenyl-2,3-diazaspiro[4.5]dec-3-ene-1,8-dione 
• 1418030-35-9 6-(4-chlorophenyl)-4-methyl-2,10-diphenyl-2,3-diazaspiro[4.5]dec-3-ene-1,8-dione 
• 1418030-36-0 6-(3-chlorophenyl)-4-methyl-2,10-diphenyl-2,3-diazaspiro[4.5]dec-3-ene-1,8-dione 
• 1418030-37-1 6-(4-fluorophenyl)-4-methyl-2,10-diphenyl-2,3-diazaspiro[4.5]dec-3-ene-1,8-dione 

Relevant articles and documents

Regioselective synthesis of 6-trifluoromethyl-1,4,5,6-tetrahydropyrazolo[3,4-b]pyran derivatives

A facile two-step procedure for the synthesis of 6-(trifluoromethyl)-1,4,5,6-tetrahydropyrazolo[3,4-b]pyran derivatives (4) from the reaction of 4-arylidene-3-methyl-1-phenyl-5-pyrazolones (1) with ethyl trifluoroacetoacetate (2), a versatile fluorinated

Amphiphile catalysed selective synthesis of 4-amino alkylated-1H-pyrazol-5-ol via Mannich aromatization preferred to the Knoevenagel-Michael type reaction in water

An economic and efficient amphiphile (SDS) catalysed one pot synthesis of the aromatized 4-amino alkylated-1H-pyrazol-5-ol via a Mannich type reaction that is preferable compared to a Knoevenagel-Michael type reaction, i.e. aromatic aldehyde, secondary amine and 3-methyl-1-phenyl-5-pyrazolinone in water, has been developed. In this selective Mannich aromatization, the reaction proceeds via a micelle stabilized imine intermediate, followed by the nucleophilic addition of 3-methyl-1-phenyl-5-pyrazolinone and aromatization in water.

Enantioselective Synthesis of Spiropyrazolone-Fused Cyclopenta[ c]chromen-4-ones Bearing Five Contiguous Stereocenters via (3+2) Cycloaddition

An enantioselective synthesis of spiropyrazolone-fused cyclopenta[c]chromen-4-ones is demonstrated via a (3+2) cycloaddition reaction. The reactions of 3-homoacylcoumarins and α,β-unsaturated pyrazolones in the presence of the cinchona-alkaloid derived hy

Enantio- And diastereoselective synthesis of b-Aryl-b-pyrazolyl a-amino acid esters via copper-catalyzed reaction of azomethine ylides with benzylidenepyrazolones

A fully stereoselective synthesis of unnatural chiral b-aryl-b-pyrazolyl a-amino acid esters via copper-catalyzed addition reactions of azomethine ylides with benzylidenepyrazolones bearing two contiguous stereogenic centers was developed. A 1H-pyrazol-5-ol was introduced by the aromatization of 3H-pyrazol-3-one in the reaction. The transformation operated at room temperature and afforded b-1H-pyrazol-5-ol-a-amino esters in high yields with good to excellent levels of diastereo- and enantioselectivity.