23901-60-2

Usage

Uses

Used in Pharmaceutical Applications:
(4Z)-5-methyl-2-phenyl-4-(phenylmethylidene)-2,4-dihydro-3H-pyrazol-3-one is used as a pharmaceutical compound for its anti-inflammatory, analgesic, and antioxidant properties. These characteristics make it a candidate for the development of new drugs targeting various conditions and diseases.
Used in Chemical Synthesis:
(4Z)-5-methyl-2-phenyl-4-(phenylmethylidene)-2,4-dihydro-3H-pyrazol-3-one is used as a starting material in the synthesis of other organic compounds. Its unique structure and functional groups can be utilized to create a variety of chemical products, potentially leading to new applications in different industries.
Used in Research and Development:
(4Z)-5-methyl-2-phenyl-4-(phenylmethylidene)-2,4-dihydro-3H-pyrazol-3-one is used as a subject of study in research and development for understanding its full potential and identifying new applications. The exploration of its biological activities and chemical properties can lead to advancements in various scientific fields.

Upstream product

• 19735-89-8 3-methyl-1-phenylpyrazolin-5(4H)-one 
• 100-52-7 benzaldehyde 
• 89-25-8 edaravone 
• 64-17-5 ethanol 
• 397878-11-4 5,5'-dimethyl-2,2'-diphenyl-1,2,1',2'-tetrahydro-4,4'-benzylidene-bis-pyrazol-3-one 
• 538-51-2 benzylidene phenylamine 
• 942-32-5 5-methyl-2-phenyl-2H-pyrazol-3-ol 
• 76086-78-7 1-phenyl-3-methyl-4-<(4-iodophenylamino)phenyl>methyl-5-pyrazolone 
• 57303-46-5 4,4'-(phenylmethylene)bis(3-methyl-1-phenyl-pyrazol-5-ol) 
• 3381-47-3 N-benzylidene-4-iodoaniline 
• 110-89-4 piperidine 
• 100-51-6 benzyl alcohol 
• 100-63-0 phenylhydrazine 

Downstream Products

• 824428-86-6 2,2''-benzylidene-bis-[1,2']biindenylidene-3,1',3'-trione 
• 94170-57-7 5,5-dimethyl-2-[(3-methyl-5-oxo-1-phenyl-4,5-dihydro-pyrazol-4-yl)-phenyl-methyl]-cyclohexane-1,3-dione 
• 53316-57-7 6-amino-1,4-dihydro-3-methyl-1,4-diphenylpyrano[2,3-c]pyrazole-5-carbonitrile 
• 68761-26-2 3-(Phenyl-hydrazono)-2-[1-phenyl-meth-(Z)-ylidene]-butyric acid hydrazide 
• 96128-56-2 1-phenyl-1-(1-phenyl-3-methyl-2-pyrazolin-5-one)-1-(1'-phenyl-3'-methyl-2'-pyrazolin-5'-thione)methane 
• 122835-54-5 3-(α-dimethylaminomethylene-α-formylmethyl)-1-phenyl-4-benzylidene-5-pyrazolone 
• 76794-82-6 diethyl<α-(3-methyl-5-oxo-1-phenyl-2-pyrazolin-4-yl)benzyl>phenylmalonate 
• 116149-61-2 3-methyl-1-phenyl-4-<α-benzyl>pyrazol-5-olate 
• 68615-38-3 1-phenyl-3-methyl-4-benzylidene-2-pyrazolin-5-thione 
• 119458-79-6 C₂₇H₂₄N₄O₂*C₄H₁₁N 

Relevant academic research and scientific papers

Regioselective synthesis of 6-trifluoromethyl-1,4,5,6-tetrahydropyrazolo[3,4-b]pyran derivatives

A facile two-step procedure for the synthesis of 6-(trifluoromethyl)-1,4,5,6-tetrahydropyrazolo[3,4-b]pyran derivatives (4) from the reaction of 4-arylidene-3-methyl-1-phenyl-5-pyrazolones (1) with ethyl trifluoroacetoacetate (2), a versatile fluorinated

NHC-Catalyzed Asymmetric Formal [4 + 2] Annulation to Construct Spirocyclohexane Pyrazolone Skeletons

A chiral N-heterocyclic carbene (NHC)-catalyzed [4 + 2] annulation of γ-chloroenals and α-arylidene pyrazolinones was developed in the absence of expensive oxidants. The reaction proceeds smoothly via a vinyl enolate intermediate to afford spirocyclohexan

Amphiphile catalysed selective synthesis of 4-amino alkylated-1H-pyrazol-5-ol via Mannich aromatization preferred to the Knoevenagel-Michael type reaction in water

An economic and efficient amphiphile (SDS) catalysed one pot synthesis of the aromatized 4-amino alkylated-1H-pyrazol-5-ol via a Mannich type reaction that is preferable compared to a Knoevenagel-Michael type reaction, i.e. aromatic aldehyde, secondary amine and 3-methyl-1-phenyl-5-pyrazolinone in water, has been developed. In this selective Mannich aromatization, the reaction proceeds via a micelle stabilized imine intermediate, followed by the nucleophilic addition of 3-methyl-1-phenyl-5-pyrazolinone and aromatization in water.

Enantioselective Synthesis of Spiropyrazolone-Fused Cyclopenta[ c]chromen-4-ones Bearing Five Contiguous Stereocenters via (3+2) Cycloaddition

An enantioselective synthesis of spiropyrazolone-fused cyclopenta[c]chromen-4-ones is demonstrated via a (3+2) cycloaddition reaction. The reactions of 3-homoacylcoumarins and α,β-unsaturated pyrazolones in the presence of the cinchona-alkaloid derived hy

A three-component, general and practical route for diastereoselective synthesis of aza-spirocyclic pyrazolonesviaa decarboxylative annulation process

An efficient, general, and practical route for highly diastereoselective synthesis of aza-spirocyclic pyrazolones from easily available α-amino acids, aldehydes, and alkylidene pyrazolones by means of a decarboxylative annulation process is reported. This

Enantio- and Diastereoselective Synthesis of β-Aryl-β-pyrazolyl α-Amino Acid Esters via Copper-Catalyzed Reaction of Azomethine Ylides with Benzylidenepyrazolones

A fully stereoselective synthesis of unnatural chiral β-aryl-β-pyrazolyl α-amino acid esters via copper-catalyzed addition reactions of azomethine ylides with benzylidenepyrazolones bearing two contiguous stereogenic centers was developed. A 1H-pyrazol-5-ol was introduced by the aromatization of 3H-pyrazol-3-one in the reaction. The transformation operated at room temperature and afforded β-1H-pyrazol-5-ol-α-amino esters in high yields with good to excellent levels of diastereo- and enantioselectivity.

Enantio- And diastereoselective synthesis of b-Aryl-b-pyrazolyl a-amino acid esters via copper-catalyzed reaction of azomethine ylides with benzylidenepyrazolones

A fully stereoselective synthesis of unnatural chiral b-aryl-b-pyrazolyl a-amino acid esters via copper-catalyzed addition reactions of azomethine ylides with benzylidenepyrazolones bearing two contiguous stereogenic centers was developed. A 1H-pyrazol-5-ol was introduced by the aromatization of 3H-pyrazol-3-one in the reaction. The transformation operated at room temperature and afforded b-1H-pyrazol-5-ol-a-amino esters in high yields with good to excellent levels of diastereo- and enantioselectivity.

Bisphosphine catalyzed sequential [3 + 2] cycloaddition and Michael addition of ynones with benzylidenepyrazolones: Via dual α′,α′-C(sp3)-H bifunctionalization to construct cyclopentanone-fused spiro-pyrazolones

A bisphosphine-catalyzed sequential [3 + 2] cycloaddition and Michael addition reaction of ynones with benzylidenepyrazolones has been developed. Under the catalysis of DPPB [1,4-bis(diphenylphosphino)butane], the reaction proceeded smoothly to give spiro-[cyclopentanone] pyrazolone derivatives in moderate to good yields with good diastereoselectivities via sequential dual α′,α′-C(sp3)-H bifunctionalization annulation. This strategy provides a novel route toward the synthesis of spiro-[cyclopentanone] pyrazolones containing three contiguous stereocenters which possess potential pharmaceutical activities.

Tosylmethylisocyanide (TosMIC) [3+2] cycloaddition reactions: A facile Van Leusen protocol for the synthesis of the new class of spirooxazolines, spiropyrrolines and Chromeno[3,4-c]pyrrols

The reactivity and chemo-, regio- and diastreo-selectivity of tosylmethyl isocyanides (TosMIC) are investigated in Van Leusen type [3 + 2] cycloaddition reactions with the various activate cyclic ketones and double C–C bonds in the synthesis of spirooxazolines, spiropyrrolines and chromeno[3,4-c]pyrrols in good to excellent yields under catalyst-free conditions without any activation at ambient temperature.

Lewis-Base-Catalyzed [1 + 2 + 2] Annulation Reaction of Morita-Baylis-Hillman Carbonates with Unsaturated Pyrazolones: Construction of All-Stereogenic Carbon Cyclopentane-Fused Dispiropyrazolones

The first Lewis-base-catalyzed unexpected [1 + 2 + 2] annulation reaction between Morita-Baylis-Hillman carbonates and unsaturated pyrazolones was developed. The multicyclic cyclopentane-fused dispiropyrazolone constructions containing five contiguous ste