1429129-62-3Relevant academic research and scientific papers
Synthesis and biological evaluation of GPR40/FFAR1 agonists containing 3,5-dimethylisoxazole
Yang, Lingyun,Zhang, Jian,Si, Lianghui,Han, Li,Zhang, Bo,Ma, Hui,Xing, Junhao,Zhao, Leilei,Zhou, Jinpei,Zhang, Huibin
, p. 46 - 58 (2016/04/19)
GPR40 is an attractive target due to its glucose-stimulated insulin secretion effect with low risk of causing hypoglycemia, which also can be seen from the clinical studies using TAK-875 (fasiglifam). In the present studies, we discovered a series of anal
Optimization of 3,5-dimethylisoxazole derivatives as potent bromodomain ligands
Hewings, David S.,Fedorov, Oleg,Filippakopoulos, Panagis,Martin, Sarah,Picaud, Sarah,Tumber, Anthony,Wells, Christopher,Olcina, Monica M.,Freeman, Katherine,Gill, Andrew,Ritchie, Alison J.,Sheppard, David W.,Russell, Angela J.,Hammond, Ester M.,Knapp, Stefan,Brennan, Paul E.,Conway, Stuart J.
, p. 3217 - 3227 (2013/06/04)
The bromodomain protein module, which binds to acetylated lysine, is emerging as an important epigenetic therapeutic target. We report the structure-guided optimization of 3,5-dimethylisoxazole derivatives to develop potent inhibitors of the BET (bromodom
