1429181-29-2

Upstream product

• 222714-37-6 4-[(1S)-1-aminoethyl]-benzoic acid, methyl ester 
• 847728-90-9 (S)-methyl 4-(1-((tert-butoxycarbonyl)amino)ethyl)benzoate 
• 1429181-26-9 tert-butyl N-[(1S)-1-[4-(hydroxymethyl)phenyl]ethyl]carbamate 
• 1429181-27-0 tert-butyl (S)-(1-(4-(chloromethyl)phenyl)ethyl)carbamate 
• 1429181-28-1 (S)-tert-butyl 1-(4-((5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methyl)phenyl)ethylcarbamate 

Relevant academic research and scientific papers

3-PYRIMIDIN-4-YL-OXAZOLIDIN-2-ONES AS INHIBITORS OF MUTANT IDH

The invention is directed to a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1-R6 are defined herein. The invention is also directed to compositions containing a compound of formula (I) and to the use of such compounds in the inhibition of mutant IDH proteins having a neomorphic activity. The invention is further directed to the use of a compound of formual (I) in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer