142921-23-1

Basic information

• Product Name: 2-(4-chlorophenyl)-1-methyl-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile
• Synonyms: 2-(4-chlorophenyl)-1-methyl-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile
• CAS NO: 142921-23-1
• Molecular Formula: C₁₃H₈ClF₃N₂
• Molecular Weight: 0
• Mol File: 142921-23-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(4-chlorophenyl)-1-methyl-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-chlorophenyl)-1-methyl-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile(142921-23-1)
• EPA Substance Registry System: 2-(4-chlorophenyl)-1-methyl-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile(142921-23-1)

Safety Data

• Hazardous Substances Data: 142921-23-1(Hazardous Substances Data)

Usage

Chemical core structure

2-(4-chlorophenyl)-1-methyl-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile has a pyrrole core structure.

Substituents

The compound features a substituted phenyl group (4-chlorophenyl) and a trifluoromethyl group.

Derivative type

It is a carboxylic acid derivative containing a nitrile group.

Industry applications

The compound has potential applications in the pharmaceutical industry.

Reactivity

The presence of chlorophenyl and trifluoromethyl groups enhances the molecule's reactivity.

Biological activity

The chlorophenyl and trifluoromethyl groups can potentially influence the compound's biological activity.

Drug development

2-(4-chlorophenyl)-1-methyl-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile may be utilized in the development of new drug candidates.

Unique structural features

The compound possesses unique structural features that can be tailored for specific purposes.

Organic synthesis

It may have potential use as a reagent in organic synthesis and chemical transformations.

Upstream product

• 151680-54-5 α-bromo-p-chloro-β-(methylamino)cinnamonitrile 
• 421-50-1 1,1,1-trifluoro-2-propanone 
• 920-37-6 2-Chloroacrylonitrile 
• 143210-01-9 2-(p-chlorophenyl)-1-methyl-5-(trifluoromethyl)-2-pyrroline-3-carbonitrile 

Downstream Products

• 122453-72-9 4-bromo-2-p-chlorophenyl-1-methyl-5-trifluoromethylpyrrole-3-carbonitrile 

Relevant articles and documents

Application of 2-aryl substituted pyrrole compound in medicine for killing oncomelania hupensis

The invention relates to an application of 2-aryl substituted pyrrole compound in a medicine for killing oncomelania hupensis and belongs to the technical field of prevention and treatment of bilharziasis, and particularly provides the chemical structure of the 2-aryl substituted pyrrole compound and a preparation method of same. The 2-aryl substituted pyrrole compound, being an active component,is used for preparing the snail killing agent in the forms of suspending agents, emulsions and micro-emulsions for killing the oncomelania hupensis. Immersion killing use amount of the 2-aryl substituted pyrrole compound being the active component of the snail killing agent is 0.1-10.00 mg/l, and immersion killing time is 24-72 h. The use amount of spray application is 1-10 g/m and action timeis 3-7 days. Experiment proves that the 2-aryl substituted pyrrole compound has killing activity on the oncomelania hupensis and is lower than a snail killing agent, niclosamide, in the prior art in toxicity on aquatic organisms. The compound can be processed to prepare the snail killing agents and applied in the field of prevention and treatment of bilharziasis.

Application of 2-aryl substituted pyrrole compound in medicine for killing biomphalarid snails

The invention relates to an application of 2-aryl substituted pyrrole compound in a medicine for killing biomphalarid snails and belongs to the technical field of prevention and treatment of bilharziasis, and particularly provides the chemical structure of the 2-aryl substituted pyrrole compound and a preparation method of same. The 2-aryl substituted pyrrole compound, being an active component, is used for preparing the snail killing agent in the forms of suspending agents, emulsions and micro-emulsions for killing the biomphalarid snail. Immersion killing use amount of the 2-aryl substitutedpyrrole compound being the active component of the snail killing agent is 0.5-10.00 mg/l, and immersion killing time is 24-72 h. Experiment proves that the 2-aryl substituted pyrrole compound has killing activity on the biomphalarid snails and is lower than a snail killing agent, niclosamide, in the prior art in toxicity on aquatic organisms. The compound can be processed to prepare the snail killing agents and applied in the field of prevention and treatment of bilharziasis.

Process for the manufacture of 2-aryl-5-perfluoroalkylpyrrole derivatives and intermediates useful therefor

There is provided a single step procedure to prepare 2-aryl-5-perfluoroalkylpyrrole derivatives directly from the perfluoroacetylated Strecker reaction product. Said pyrrole derivatives are insecticidal and also useful as precursors to other insecticidal arylpyrrole compounds. Further provided are amide nitrile intermediates, useful in the preparation of insecticidal arylpyrrole compounds.

Process for the manufacture of 2-aryl-5 perfluoroalkylpyrrole derivatives

There is provided a single step procedure to prepare 2-aryl-5-perfluoroalkylpyrrole derivatives directly from the perfluoroacetylated Strecker reaction product. Said pyrrole derivatives are insecticidal and also useful as precursors to other insecticidal arylpyrrole compounds. Further provided are amide nitrile intermediates, useful in the preparation of insecticidal arylpyrrole compounds.

A process for the manufacture of 2 aryl 5 perfluoroalkylpyrrole derivatives and intermediates useful therefor

There is provided a single step procedure to prepare 2-aryl-5-perfluoroalkylpyrrole derivatives directly from the perfluoroacetylated Strecker reaction product. Said pyrrole derivatives are insecticidal and also useful as precursors to other insecticidal arylpyrrole compounds. Further provided are amide nitrile intermediates, useful in the preparation of insecticidal arylpyrrole compounds.

Process for the preparation of insecticidal, acaricidal and nematicidal 2-aryl-3-substituted-5-(trifluoromethyl)pyrrole compounds

There is provided a process for the preparation of 2-aryl-3-substituted-5-(trifluoromethyl)pyrrole compounds which are useful as insecticidal, acaricidal and nematicidal agents.

Process for the preparation of 2-aryl-1-substituted-5-(trifluoromethyl) pyrrole compounds useful as insecticidal, acaricidal and nematocidal agents and as intermediates for the manufacture of said agents

A method for the preparation of insecticidal arylpyrroles, and intermediates for the manufacture of insecticidal arylpyrroles, via a single step 1,3-dipolar cycloaddition process is provided.