142927-07-9

Usage

Uses

Used in Pharmaceutical Synthesis:
(R)-α-methyl-4-nitrophenylacetic acid is used as a key intermediate in the synthesis of pharmaceuticals for [application reason] its reactivity and chiral nature, which are essential in the development of new drugs with specific therapeutic effects.
Used in Agrochemical Production:
(R)-α-methyl-4-nitrophenylacetic acid is used as a building block in the production of agrochemicals for [application reason] its ability to be incorporated into various chemical structures, contributing to the development of effective and targeted agrochemicals.
Used in Organic Chemistry:
(R)-α-methyl-4-nitrophenylacetic acid is used as a versatile reagent in organic chemistry for [application reason] its reactivity, particularly due to the nitro group, which allows for a wide range of chemical reactions and the synthesis of diverse organic compounds.
Used in Antibacterial Applications:
(R)-α-methyl-4-nitrophenylacetic acid is used as an antibacterial agent for [application reason] its potential pharmacological activities, which have been studied for their effectiveness against certain bacterial strains.
Used in Anti-inflammatory Applications:
(R)-α-methyl-4-nitrophenylacetic acid is used as an anti-inflammatory agent for [application reason] its demonstrated potential to reduce inflammation, which can be beneficial in the treatment of various conditions characterized by inflammation.

Upstream product

• 19910-33-9 2-(4-nitrophenyl)propanoic acid 
• 50712-63-5 2-(4-nitrophenyl)-propionitrile 
• 100-13-0 4-nitrostyrene 
• 201230-82-2 carbon monoxide 

Downstream Products

• 533931-47-4 methyl 2-(4-nitrophenyl)propanoate 

Relevant academic research and scientific papers

Palladium-Catalyzed Asymmetric Markovnikov Hydroxycarbonylation and Hydroalkoxycarbonylation of Vinyl Arenes: Synthesis of 2-Arylpropanoic Acids

Asymmetric hydroxycarbonylation is one of the most fundamental yet challenging methods for the synthesis of carboxylic acids. Herein, we reported the development of a palladium-catalyzed highly enantioselective Markovnikov hydroxycarbonylation of vinyl arenes with CO and water. A monodentate phosphoramidite ligand L6 plays vital role in the reaction. The reaction tolerates a range of functional groups, and provides a facile and atom-economical approach to an array of 2-arylpropanoic acids including several commonly used non-steroidal anti-inflammatory drugs. The catalytic system has also enabled an asymmetric Markovnikov hydroalkoxycarbonylation of vinyl arenes with alcohols to afford 2-arylpropanates. Mechanistic investigations suggested that the hydropalladation is irreversible and is the regio- and enantiodetermining step, while hydrolysis/alcoholysis is probably the rate-limiting step.

2-aryl-propionic acids and derivatives and pharmaceutical compositions containing them

The present invention relates to (R,S) 2-aryl-propionic acids and derivatives, their single enantiomer (S) and to pharmaceutical compositions containing them, which are used in the prevention and treatment of tissue damage due to the exacerbated recruitment of polymorphonucleated neutrophils (PMN leukocytes) at inflammation sites. The present invention provides compounds for use in the treatment of transient cerebral ischemia, bullous pcmphigo, rheumatoid arthritis, idiopathic fibrosis, glomerulonephritis and damages caused by ischemia and reperfusion.

High-performance liquid chromatography separation of enantiomers of mandelic acid and its analogs on a chiral stationary phase

The enantiomers of mandelic acid and its analogs have been chromatographically separated on a chiral stationary phase (CSP) derived from 4-(3,5-dinitrobenzamido) tetrahydrophenanthrene. The rationale of separations of these compounds is discussed with respect to the method development for determining enantiomeric purity and possibility of obtaining enantiomerically pure materials by high-pressure liquid chromatography. The relationship of analyte structure to the extent of enantiomeric separation has been examined and separation factors (a) are presented for various groups of structurally related compounds. Chiral recognition models have been suggested to account for the observed separations. These models provide mechanistic insights into the chiral recognition process.

Enantioselective hydrolysis of various racemic α-substituted arylacetonitriles using Rhodococcus sp. CGMCC 0497

The enantioselective hydrolysis of 17 racemic α-substituted arylacetonitriles by Rhodococcus sp. CGMCC 0497 is described. The corresponding (R)-amides and (S)-acids were obtained with excellent enantiomeric excess in most cases. The effect of steric and electronic factors on the outcome of the reactions are discussed here. The results prove that nitrile-converting enzymes are efficient tools for the synthesis of sterically unencumbered chiral α-arylpropionic acids and amides.