1429292-86-3Relevant academic research and scientific papers
PK/PD Disconnect Observed with a Reversible Endothelial Lipase Inhibitor
Hangeland, Jon J.,Abell, Lynn M.,Adam, Leonard P.,Jiang, Ji,Friends, Todd J.,Haque, Lauren E.,Neels, James,Onorato, Joelle M.,Chen, Alice Ye A.,Taylor, David S.,Yin, Xiaohong,Harrity, Thomas W.,Basso, Michael D.,Yang, Richard,Sleph, Paul G.,Gordon, David A.,Huang, Christine S.,Wexler, Ruth R.,Finlay, Heather J.,Lawrence, R. Michael
, p. 673 - 678 (2018/07/25)
Screening of a small set of nonselective lipase inhibitors against endothelial lipase (EL) identified a potent and reversible inhibitor, N-(3-(3,4-dichlorophenyl)propyl)-3-hydroxy-1-methyl-2-oxo-1,2-dihydropyridine-4-carboxamide (5; EL IC50 = 6
PYRROLINONE CARBOXAMIDE COMPOUNDS USEFUL AS ENDOTHELIAL LIPASE INHIBITORS
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Paragraph 00232; 00295, (2013/04/13)
The present invention provides compounds of Formula (I) or Formula (III): [INSERT CHEMICAL STRUCTURE HERE] (I) [INSERT CHEMICAL STRUCTURE HERE] (III) as defined in the specification and compositions comprising any of such novel compounds. These compounds
