1429294-47-2

Upstream product

• 552-89-6 2-nitro-benzaldehyde 
• 67718-36-9 N-[2-(aminocarbonyl)phenyl]-2-nitrobenzamide 
• 552-16-9 ortho-nitrobenzoic acid 
• 62-23-7 4-nitro-benzoic acid 
• 1429294-62-1 4-amino-N-(2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)benzamide 
• 1429294-60-9 N-(2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)-4-nitrobenzamide 
• 1429294-59-6 N¹-(2-(2-aminophenyl)quinazolin-4-yl)-N³,N³-dimethylpropane-1,3-diamine 
• 1429294-58-5 N¹,N¹-dimethyl-N³-(2-(2-nitrophenyl)quinazolin-4-yl)propane-1,3-diamine 
• 91961-09-0 4-chloro-2-(2-nitrophenyl)quinazoline 
• 36567-87-0 2-(2'-nitrophenyl)-4(3H)-quinazolinone 
• 109-01-3 1-methyl-piperazine 
• 1429294-64-3 4-(2-chloroacetamido)-N-(2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)benzamide 
• 122-04-3 4-nitro-benzoyl chloride 
• 28144-70-9 anthranilic acid amide 

Relevant academic research and scientific papers

N-(4-(quinazolin-2-yl)phenyl)benzamide derivatives with potent anti-angiogenesis activities: Synthesis and evaluation

Expanding our studies on the anti-angiogenesis activities of 2,4-disubstituted quinazoline derivatives [8], a series of novel N-(2-(quinazolin-2-yl)phenyl)benzamide (SZ) derivatives were designed and synthesized. Cytotoxicity assays indicated that most of these compounds displayed similar cytotoxicity against tumor cells in comparison with our previously reported, but showed a higher cytotoxicity against HUVECs. The SZ derivatives showed a remarkable inhibitive effect against the migration and adhesion of HUVECs, in addition to demonstrating significant in vivo anti-angiogenesis activities in the chick embryo chorioallantoic membrane (CAM) assay. The results proved that the introduction of an aryl group with a basic amide side chain on the 4′ position linked to the amide of the C-2 substituted quinazoline scaffold is an effective approach to improve the anti-angiogenic activity of quinazoline derivatives.

New quinazoline derivatives for telomeric G-quadruplex DNA: Effects of an added phenyl group on quadruplex binding ability

To improve the selectivity of indoloquinoline or benzofuroquinoline derivatives, we previously reported several quinazoline derivatives [17]. These compounds could mimic a tetracyclic aromatic system through intramolecular hydrogen bond. Studies showed that these quinazoline derivatives were effective and selective telomeric G-quadruplex ligands. With this encouragement, here we synthesized a series of N-(2-(quinazolin-2-yl)phenyl)benzamide (QPB) compounds as modified quinazoline derivatives. In this modification, a phenyl group was introduced to the aromatic core. The evaluation results showed that part of QPB derivatives had stronger binding ability and better selectivity for telomeric G-quadruplex DNA than LZ-11, the most potential compound of reported quinazoline derivatives. Furthermore, telomerase inhibition of QPB derivatives and their cellular effects were studied.