1429309-01-2Relevant academic research and scientific papers
Synthesis of precursors of 4-phosphino-1h-pyrrole-3-carbaldehyde derivatives
Smaliy, Radomyr V.,Chaykovskaya, Aleksandra A.,Shtil, Nataliya A.,Savateev, Aleksandr S.,Kostyuk, Aleksandr N.
, p. 146 - 151 (2013/04/24)
In this work, possible approaches to the synthesis of 1,2,5-substituted 4-phosphoryl-3-formylpyrroles have been considered. As a result, two methods for the synthesis of 4-(diphenylphosphoryl)-1-(4-ethoxyphenyl)-2,5-dimethyl-1H- pyrrole-3-carbal-dehyde were proposed; the highest yields gives formylation of 3-(diphenylphosphorothioyl)-1-(4-ethoxyphenyl)-2,5-dimethyl-1H-pyrrole. The formyl fragment was successfully converted into a Schiff base with phenethylamine, and the phosphoryl group has been reduced to phosphine with silicochloroform, which suggests a promising approach to the synthesis of chiral bidentate phosphine ligands. 2013 Wiley Periodicals, Inc. Heteroatom Chem 24:146-151, 2013; View this article online at wileyonlinelibrary.com. DOI 10.1002/hc.21069
