1429329-55-4Relevant academic research and scientific papers
Oxone-DMSO Triggered Methylene Insertion and C(sp2)-C(sp3)-H-C(sp2) Bond Formation to Access Functional Bis-Heterocycles
Bharatam, Prasad V.,Dubey, Gurudutt,Hussain, Yaseen,Kour, Jaspreet,Sahoo, Subash C.,Sawant, Sanghapal D.,Venkateswarlu, Vunnam,Verma, Praveen K.
supporting information, p. 4951 - 4962 (2020/05/08)
Metal-free insertion of a methylene group was achieved for the construction of a new C(sp2)-C(sp3)-H-C(sp2) bond in order to prepare novel bis-heterocyclic scaffolds. The complete mechanistic investigations included experimental study and DFT calculations, and various symmetric and unsymmetric bis-pyrazoles as well as other pyrazole-based bis-heterocyclic molecules were prepared in moderate to high yields. Further modification of the bridged methylene group in the unsymmetric pyrazoles generated a chiral center to extend the scope of this method.
