21018-71-3

Usage

Belongs to the pyrazole family

2-(3,5-DIMETHYL-1H-PYRAZOL-1-YL)PYRIDINE is a compound that belongs to the pyrazole family, which is a group of organic compounds that contain a five-membered ring with two nitrogen atoms.

Contains a pyridine ring

2-(3,5-DIMETHYL-1H-PYRAZOL-1-YL)PYRIDINE contains a pyridine ring, which is a six-membered aromatic ring with one nitrogen atom.

Molecular weight

The molecular weight of 2-(3,5-DIMETHYL-1H-PYRAZOL-1-YL)PYRIDINE is 200.24 g/mol.

Used in pharmaceutical and agrochemical research

This chemical is primarily used in pharmaceutical and agrochemical research as a building block for the synthesis of various functionalized heterocycles.

Potential use as an anti-inflammatory and anticancer agent

2-(3,5-DIMETHYL-1H-PYRAZOL-1-YL)PYRIDINE has been studied for its potential use as an anti-inflammatory and anticancer agent.

High reactivity and versatility

2-(3,5-DIMETHYL-1H-PYRAZOL-1-YL)PYRIDINE is known for its high reactivity and versatility, making it a valuable tool in organic synthesis.

Upstream product

• 109-04-6 2-bromo-pyridine 
• 67-51-6 3,5-dimethyl-1H-pyrazole 
• 109-09-1 2-chloropyridine 
• 123-54-6 acetylacetone 
• 4930-98-7 pyrid-2-ylhydrazine 

Downstream Products

• 1429329-55-4 bis(3,5-dimethyl-1-(pyridin-2-yl)-1H-pyrazol-4-yl)methane 
• 663219-55-4 SnPh₂Br₂(3,5-dimethyl-1-(2'-pyridyl)pyrazole) 
• 104957-17-7 triphenylphosphine 3,5-dimethyl-1-(2'-pyridyl)pyrazolegold(I) perchlorate 

Relevant academic research and scientific papers

A four-coordinate Cu(I)–N-heterocyclic carbene complex: Synthesis, structure, properties, and application in amination for the synthesis of 1-(2-N-heteroaryl)-1H-pyrazoles

A new luminescent, cationic, heteroleptic, four-coordinate Cu(I)–N-heterocyclic carbene complex [Cu(Br-Pyim)(POP)](PF6) is successfully prepared and characterized, where Br-Pyim and POP are 1-(6-bromopyridin-2-yl)imidazole-3-benzyl-2-ylidene an

Synthesis of heteroleptic iridium complexes with sterically hindered methyl groups on pyrazole ligands for efficient yellow and green light-emitting electrochemical cells

We report the synthesis of four cationic iridium complexes, [Ir(ppy)2(mepzpy)]PF6 (1a), [Ir(dfppy)2(mepzpy)]PF6 (1b), [Ir(ppy)2(dmpzpy)]PF6 (2a), and [Ir(dfppy)2(dmpzpy)]PF6 (2b), containing the methyl-substituted pyrazole-based ancillary ligand and the phenylpyridine-based cyclometalating ligands. UV-visible, photoluminescence (PL), and voltammetric measurements were made to study the photophysical and electrochemical properties of complexes 1a-2b. Light-emitting electrochemical cells (LECs) were fabricated, which showed yellow emission for complexes 1a and 2a and green emission for complexes 1b and 2b. The LEC incorporating 2b exhibited a high luminance of 658 cd m-2 and a current efficiency of 0.34 cd A-1. The higher luminance and efficiency of the device based on 2b were due to the smooth surface morphology and the presence of sterically hindered dimethyl groups on the ancillary ligand (dmpzpy), which causes a more balanced charge carrier injection and recombination.

Oxone-DMSO Triggered Methylene Insertion and C(sp2)-C(sp3)-H-C(sp2) Bond Formation to Access Functional Bis-Heterocycles

Metal-free insertion of a methylene group was achieved for the construction of a new C(sp2)-C(sp3)-H-C(sp2) bond in order to prepare novel bis-heterocyclic scaffolds. The complete mechanistic investigations included experimental study and DFT calculations, and various symmetric and unsymmetric bis-pyrazoles as well as other pyrazole-based bis-heterocyclic molecules were prepared in moderate to high yields. Further modification of the bridged methylene group in the unsymmetric pyrazoles generated a chiral center to extend the scope of this method.

Controllable access to multi-substituted imidazoles: Via palladium(II)-catalyzed C-C coupling and C-N condensation cascade reactions

A novel and efficient protocol for the synthesis of various 2,4-disubstituted, 1,2,4-trisubstituted and 1,2,4,5-tetra-substituted imidazoles via cascade palladium catalyzed C-C coupling followed by intramolecular C-N bond formation was developed. Readily accessible boronic acids and N-substituted-2-aminoacetonitriles were firstly reported as starting materials to construct di-, tri-, and tetra-substituted imidazoles in good to excellent yield.

Design, synthesis, and properties of a series of charged iridium(III) complexes with a neutral bidentate ligand for deep-blue phosphorescent emitter

We herein report a series of charged iridium(III) complexes with a neutral bidentate ligand for blue phosphorescent emitter. A molecular design bearing a 2-(3,5-dimethyl-1H-pyrazol-1-yl)pyridine ligand proved suitable for efficient blue emission according to the comparison of photoluminescent properties of the complexes. Its Commission Internationale de L'Eclairage x,y-coordinates (CIEx,y) in solution was estimated to be (0.17, 0.18), indicating that the complex with the ligand is promising candidate for a deep-blue emitter. We further demonstrated that this complex displays blue electroluminescence by successfully integrating it in a light-emitting device.

PRODUCING METHOD OF NITROGEN-CONTAINING ORGANIC COMPOUND

A hydrazine-carbon dioxide-binding compound or hydrazine derivatives 2 carbonyl group react with a compound having one or more nitrogen-containing organic for preparing the compounds of relates to method.

Palladium catalyzed addition of arylboronic acid or indole to nitriles: Synthesis of aryl ketones

Aryl ketones can be synthesized conveniently by a palladium catalyzed addition of arylboronic acid to nitriles in aqueous triflic acid. This catalytic system was extended to the addition of unprotected indoles to nitriles under a slightly modified condition to produce 3-acyl indoles in good yields.

Efficient N-arylation catalyzed by a copper(I) pyrazolyl-nicotinic acid system

Catalyst 6-(1H-pyrazol-1-yl)nicotinic acid L-CuCl behaves as a very active promoter of the N-arylation reactions, as it has been demonstrated with varieties of substrates under mild reaction conditions. A Cu(I) complex based on L of precatalyst has been isolated by a hydrothermal method and structurally characterized.

Layered zirconium sulfophenyl phosphonate as heterogeneous catalyst in the synthesis of pyrazoles and 4,5,6,7-tetrahydro-1(2)H-indazoles

Pyrazoles and tetrahydroindazoles may be prepared by condensation of 1,3-diones and hydrazines under layered zirconium sulfophenyl phosphonate catalysis, in solvent-free conditions. Georg Thieme Verlag Stuttgart.

NMR (1H and 13C) and IR Studies of Dioxouranium(VI) Complexes with a Bidentate Pyridyl-Pyrazole Ligand

The bidentate ligand, 3,5-dimethyl-1(2'-pyridyl)pyrazole (DMPP), reacts with UO2(NO3)2 and UO2(NCS)2 in ethanol to form yellow, crystalline, diamagnetic and non-electrolytic complexes and .The IR spectra indicate coordination of the thiocyanato group through the N-end and of the nitrato group through the O-atoms in a bidentate manner.The IR bands also suggest the presence of linear UO2(2+) moiety.The 1H and 13C NMR spectra adequately confirm the above assignments.The mass spectra of the complexes show the molecular ion peak and the fragmentation pattern of the ligand, but not of the original complexes.