1429427-69-9Relevant articles and documents
Structural modifications of 4-aryl-4-oxo-2-aminylbutanamides and their acetyl- and butyrylcholinesterase inhibitory activity. Investigation of AChE-ligand interactions by docking calculations and molecular dynamics simulations
Vitorovi?-Todorovi?, Maja D.,Koukoulitsa, Catherine,Jurani?, Ivan O.,Mandi?, Ljuba M.,Drakuli?, Branko J.
, p. 158 - 175 (2014/06/09)
Congeneric set of thirty-eight 4-aryl-4-oxo-2-(N-aryl/cycloalkyl) butanamides has been designed, synthesized and evaluated for acetyl- and butyrylcholinesterase inhibitory activity. Structural variations included cycloalkylamino group attached to C2 posit