1429427-97-3

Upstream product

• 80937-20-8 (E)-4-(3',4'-dichlorophenyl)-4-oxo-2-butenoic acid 
• 62-53-3 aniline 
• 95-50-1 1,2-dichloro-benzene 

Downstream Products

• 70012-39-4 4-(3,4-dichloro-phenyl)-4-oxo-N-phenyl-2-piperidin-1-yl-butyramide 
• 70012-40-7 2-Benzylamino-4-(3,4-dichloro-phenyl)-4-oxo-N-phenyl-butyramide 

Relevant academic research and scientific papers

(E)-4-Aryl-4-oxo-2-butenoic acid amides, chalcone-aroylacrylic acid chimeras: Design, antiproliferative activity and inhibition of tubulin polymerization

Antiproliferative activity of twenty-nine (E)-4-aryl-4-oxo-2-butenoic acid amides against three human tumor cell lines (HeLa, FemX, and K562) is reported. Compounds showed antiproliferative activity in one-digit micromolar to submicromolar concentrations.