142944-48-7

Basic information

• Product Name: Piperazine, 1-(3-broMopropyl)-4-(3-chlorophenyl)-
• Synonyms: Piperazine, 1-(3-broMopropyl)-4-(3-chlorophenyl)-
• CAS NO: 142944-48-7
• Molecular Formula: C₁₃H₁₈BrClN₂
• Molecular Weight: 317.65242
• Mol File: 142944-48-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Piperazine, 1-(3-broMopropyl)-4-(3-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Piperazine, 1-(3-broMopropyl)-4-(3-chlorophenyl)-(142944-48-7)
• EPA Substance Registry System: Piperazine, 1-(3-broMopropyl)-4-(3-chlorophenyl)-(142944-48-7)

Safety Data

• Hazardous Substances Data: 142944-48-7(Hazardous Substances Data)

Upstream product

• 13078-15-4 1-(3-chlorophenyl)piperazine hydrochloride 
• 109-64-8 1,3-dibromo-propane 
• 186790-11-4 tert-butyl 4-(3-chlorophenyl)piperazine-1-carboxylate 
• 625-99-0 3-iodochlorobenzene 
• 6640-24-0 N-(m-chlorophenyl)piperazine 

Downstream Products

• 19794-93-5 trazodone 
• 1026842-10-3 5-acetyl-4-amino-2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-6-methylpyridazin-3(2H)-one 
• 502135-10-6 4-amino-2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-5-(1-hydroxyethyl)-6-methylpyridazin-3(2H)-one 
• 502135-06-0 6-{3-[4-(3-chloro-phenyl)-piperazin-1-yl]-propyl}-3,4-dimethyl-6H-isoxazolo[3,4-d]pyridazin-7-one 

Relevant articles and documents

Efficient copper-catalyzed cross-coupling of 1-Boc-piperazine with aryl iodides and its application in the synthesis of trazodone

A convenient and practical strategy is developed for the cross-coupling of N-Boc protected piperazines with aryl iodides using CuBr/1,1′-bi-2- naphthol as the catalyst and K3PO4 as the base. The protocol affords N-arylated piperazine products in moderate to good yields under the optimized conditions. The application of this catalytic system to the synthesis of trazodone is also successfully demonstrated using commercially available substrates.

[(3-Chlorophenyl)piperazinylpropyl]pyridazinones and analogues as potent antinociceptive agents

A number of [(3-chlorophenyl)piperazinylpropyl]pyridazinones and the corresponding isoxazolopyridazinones, showing the arylpiperazinyl substructure present in very potent antinociceptive agents reported in the literature, were synthesized and tested for t