142947-89-5Relevant academic research and scientific papers
Synthesis of a homologous series of ketomethylene arginyl pseudodipeptides and application to low molecular weight hirudin-like thrombin inhibitors
DiMaio,Gibbs,Lefebvre,Konishi,Munn,Shi Yi Yue,Hornberger
, p. 3331 - 3341 (1992)
The design of low molecular weight thrombin inhibitors IIa-d (hirutonins) that bind concurrently with the enzyme's catalytic site and auxiliary 'anion- binding exosite' for fibrinogen recognition is reported. A practical synthesis of the required homologo
