Synthesis of a homologous series of ketomethylene arginyl pseudodipeptides and application to low molecular weight hirudin-like thrombin inhibitors

Article abstract of DOI:10.1021/jm00096a004

The design of low molecular weight thrombin inhibitors IIa-d (hirutonins) that bind concurrently with the enzyme's catalytic site and auxiliary 'anion- binding exosite' for fibrinogen recognition is reported. A practical synthesis of the required homologo