1429481-45-7

Basic information

• Product Name: (E)-ethyl 4-(3-(4-(dodecyloxy)phenyl)acryloyl)-3-hydroxybenzoate
• CAS NO: 1429481-45-7
• Molecular Weight: 480.645
• Mol File: 1429481-45-7.mol

Chemical Properties

• CAS DataBase Reference: (E)-ethyl 4-(3-(4-(dodecyloxy)phenyl)acryloyl)-3-hydroxybenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-ethyl 4-(3-(4-(dodecyloxy)phenyl)acryloyl)-3-hydroxybenzoate(1429481-45-7)
• EPA Substance Registry System: (E)-ethyl 4-(3-(4-(dodecyloxy)phenyl)acryloyl)-3-hydroxybenzoate(1429481-45-7)

Safety Data

• Hazardous Substances Data: 1429481-45-7(Hazardous Substances Data)

Upstream product

• 24083-19-0 4-n-dodecyloxybenzaldehyde 
• 860709-20-2 hydroxy-terephthalic acid-4-ethyl ester 

Downstream Products

• 1429481-41-3 (E)-3-(carboxymethoxy)-4-(3-(4-(dodecyloxy)phenyl)acryloyl)benzoic acid 
• 1429481-51-5 C₃₄H₄₆O₇ 

Relevant articles and documents

Structure-based drug design using GPCR homology modeling: Toward the discovery of novel selective CysLT2 antagonists

3D structure of CysLT2 receptor was constructed by using homology modeling and molecular simulations. The binding pocket of CysLT2 receptor and the proposition of the interaction mode between CysLT2 and HAMI3379 were identified. A series of dicarboxylated chalcones was then virtually evaluated through molecular docking studies. A total of six compounds 13a-f with preferable scores was further synthesized and tested for CysLT2 antagonistic activities by determination of the cytosolic free Ca2+ levels in HEK293 cells. Compounds 13e and 13f exhibited potent and selective CysLT2 antagonistic activities with IC50 values being 7.5 and 0.25 μM, respectively.