1429485-53-9

Upstream product

• 3815-80-3 3-(p-anisyl)sydnone 
• 22094-69-5 N-(4-methoxyphenyl)glycine 
• 50845-77-7 N-(4-methoxy)phenylglycine ethyl ester 
• 104-94-9 4-methoxy-aniline 
• 680-15-9 2,2-difluoro-2-(fluorosulfonyl)acetate 
• 201282-63-5 4-iodo-3-(4-methoxyphenyl)-3H-1,2,3-oxadiazol-1-ium-5-olate 
• 1051944-03-6 3,3,3-trifluoro-2-(p-methoxyphenylamino)-propanoic acid 
• 1429485-46-0 (Z)-methyl 3,3,3-trifluoro-2-(para-methoxyphenylimino)propanoate 
• 2101-87-3 p-methoxy-phenylazide 
• 14796-89-5 4-methoxy-N-(triphenylphosphoran-ylidene)-aniline 

Downstream Products

• 1429486-35-0 1-(4-methoxy-3-nitrophenyl)-3-phenyl-5-trifluoromethyl-1H-pyrazole 
• 1429485-75-5 1-(4-methoxyphenyl)-3-phenyl-5-(trifluoromethyl)-1H-pyrazole 
• 1429485-77-7 1-(p-methoxyphenyl)-3-n-butyl-5-trifluoromethyl-1H-pyrazole 
• 1429485-79-9 1-(p-methoxyphenyl)-3-cyclopropyl-5-trifluoromethyl-1H-pyrazole 

Relevant academic research and scientific papers

Discovery of Fluorogenic Diarylsydnone-Alkene Photoligation: Conversion of ortho-Dual-Twisted Diarylsydnones into Planar Pyrazolines

A small library of diarylsydnones (DASyds) was constructed based on aryl-pairing combinations and subjected to click reaction toward alkenes under photoirradiation with high efficiency. We were able to demonstrate the utility of DASyds for highly fluorescent turn-on ligation targeting the trans-cyclooct-4-en-1-ol moieties on protein.

Synthesis of 4-fluoromethylsydnones and their participation in alkyne cycloaddition reactions

We report the synthesis and some structural studies of 4-trifluoromethyl, 4-difluoromethyl-, and 4-monofluoromethylsydnones. All but the latter compounds are stable and represent effective precursors to a range of pyrazoles after cycloaddition reactions with alkynes. The cycloadditions are generally highly regioselective and provide 5-fluoromethylpyrazole products, although we have observed that Bn-substituted sydnones can provide an unexpected alkyne insertion mode that generates the 3-fluoromethyl isomer.