1429486-61-2

Upstream product

• 14484-83-4 4-formyl-3-phenyl-sydnone 
• 4918-36-9 4-(ethoxycarbonyl)-N-phenylsydnone 
• 508191-77-3 3-phenylsydnone 

Downstream Products

• 1429486-64-5 2-(1-phenyl-5-difluoromethyl-1H-pyrazol-3-yl)-pyridine 
• 1429486-74-7 2-(1-phenyl-5-difluoromethyl-1H-pyrazol-4-yl)pyridine 
• 1429486-66-7 1-phenyl-3-cyclopropyl-5-difluoromethyl-1H-pyrazole 
• 1429486-68-9 1-phenyl-3-(3-chloro)propyl-5-difluoromethyl-1H-pyrazole 
• 1429486-70-3 ethyl 1-phenyl-5-difluoromethyl-1H-pyrazole-3-carboxylate 
• 1187935-83-6 ethyl 1-phenyl-5-difluoromethyl-1Hpyrazole-4-carboxylate 

Relevant academic research and scientific papers

Synthesis of 4-fluoromethylsydnones and their participation in alkyne cycloaddition reactions

We report the synthesis and some structural studies of 4-trifluoromethyl, 4-difluoromethyl-, and 4-monofluoromethylsydnones. All but the latter compounds are stable and represent effective precursors to a range of pyrazoles after cycloaddition reactions with alkynes. The cycloadditions are generally highly regioselective and provide 5-fluoromethylpyrazole products, although we have observed that Bn-substituted sydnones can provide an unexpected alkyne insertion mode that generates the 3-fluoromethyl isomer.