14484-83-4

Basic information

• Product Name: 4-formyl-3-phenyl-sydnone
• Synonyms: 4-formyl-3-phenyl-sydnone
• CAS NO: 14484-83-4
• Molecular Weight: 190.158
• Mol File: 14484-83-4.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 4-formyl-3-phenyl-sydnone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-formyl-3-phenyl-sydnone(14484-83-4)
• EPA Substance Registry System: 4-formyl-3-phenyl-sydnone(14484-83-4)

Safety Data

• Hazardous Substances Data: 14484-83-4(Hazardous Substances Data)

Upstream product

• 508191-77-3 3-phenylsydnone 
• 93-61-8 N-methyl-N-phenylformamide 
• 103-01-5 N-Phenylglycine 
• 62-53-3 aniline 
• 6415-68-5 N-nitroso-N-phenylglycine 
• 68-12-2 N,N-dimethyl-formamide 
• 4918-36-9 4-(ethoxycarbonyl)-N-phenylsydnone 

Downstream Products

• 67441-82-1 4-[((E)-4-methoxy-phenylimino)-methyl]-3-phenyl-sydnone 
• 95768-68-6 3-phenyl-4-{[(7⁽⁹⁾H-purin-6-yl)-hydrazono]-methyl}-sydnone 
• 508191-77-3 3-phenylsydnone 
• 14484-87-8 3-phenyl-4-formylsydnone thiosemicarbazone 
• 1394248-97-5 1-piperidinomethyl-3-[1-(4-isobutylphenyl)ethyl]-4-(3-phenyl-4-sydnonylidene)amino-1,2,4-triazol-5-thione 
• 1394248-99-7 1-N-ethyl-piperazinomethyl-3-[1-(4-isobutylphenyl)ethyl]-4-(3-phenyl-4-sydnonylidene)amino-1,2,4-triazol-5-thione 

Relevant articles and documents

Reaction of some substituted 3-aryl-4-formylsydnones with tetra-oacetyl-β-d-galactopyranosyl)thiosemicarbazide

Background: Thiosemicarbazones containing mono- or disaccharide moieties reveal several various remarkable biological activities; therefore these compounds have been focused in organic syntheses. Sydnone ring is the potential basic pharmacodynamic nucleus

Synthesis of 4-fluoromethylsydnones and their participation in alkyne cycloaddition reactions

We report the synthesis and some structural studies of 4-trifluoromethyl, 4-difluoromethyl-, and 4-monofluoromethylsydnones. All but the latter compounds are stable and represent effective precursors to a range of pyrazoles after cycloaddition reactions with alkynes. The cycloadditions are generally highly regioselective and provide 5-fluoromethylpyrazole products, although we have observed that Bn-substituted sydnones can provide an unexpected alkyne insertion mode that generates the 3-fluoromethyl isomer.

Regioselective reaction: Synthesis, characterization and pharmacological activity of some new Mannich and Schiff bases containing sydnone

A novel series of 1-substituted aminomethyl-3-[1-(4-isobutylphenyl)ethyl]- 4-(3-aryl-4-sydnonylidene) amino-1,2,4-triazol-5-thiones (9), was prepared from the 3-[1-(4-isobutylphenyl)ethyl]-4-(3-aryl-4-sydnonylidene) amino 5-mercapto-1,2,4-triazoles (8) by aminomethylation with formaldehyde and secondary amine. The structures of Schiff bases (8) and Mannich bases (9) were characterized on the basis of IR, NMR, mass spectra1 data and elemental analysis. The newly synthesized compounds were screened for their anti-inflammatory and analgesic activities. Mannich bases (9) carrying piperidine and morpholine residues showed promising anti-inflammatory and analgesic activity.