14484-83-4

Upstream product

• 508191-77-3 3-phenylsydnone 
• 93-61-8 N-methyl-N-phenylformamide 
• 103-01-5 N-Phenylglycine 
• 62-53-3 aniline 
• 6415-68-5 N-nitroso-N-phenylglycine 
• 4918-36-9 4-(ethoxycarbonyl)-N-phenylsydnone 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 508191-77-3 3-phenylsydnone 
• 14484-87-8 3-phenyl-4-formylsydnone thiosemicarbazone 
• 763124-85-2 3-phenyl-4-formylsydnone 4-phenylthiosemicarbazone 
• 1152660-20-2 3-phenyl-4-formylsydnone p-methylbenzoylhydrazone 
• 1219706-16-7 C₁₅H₁₀N₆O₂S 
• 1279692-59-9 C₁₇H₁₁N₅O₂S 
• 1394248-97-5 1-piperidinomethyl-3-[1-(4-isobutylphenyl)ethyl]-4-(3-phenyl-4-sydnonylidene)amino-1,2,4-triazol-5-thione 

Relevant academic research and scientific papers

Reaction of some substituted 3-aryl-4-formylsydnones with tetra-oacetyl-β-d-galactopyranosyl)thiosemicarbazide

Background: Thiosemicarbazones containing mono- or disaccharide moieties reveal several various remarkable biological activities; therefore these compounds have been focused in organic syntheses. Sydnone ring is the potential basic pharmacodynamic nucleus

Design, docking studies and molecular iodine catalyzed synthesis of benzo[a]xanthen-one derivatives as hyaluronidase inhibitors

A series of novel benzo[a]xanthen-11(12H)-one derivatives 4a–m were designed and subjected to docking studies. The title compounds were synthesized from 3-aryl-4-formylsydnones 1a–m, β-naphthol and dimedone in presence of molecular iodine as a catalyst an

Synthesis of novel imidazo[2,1-b][1,3,4]thiadiazoles appended to sydnone as anticancer agents

A novel series of 3-aryl-4{6′-(6′′-substituted-coumarin- 3′′-yl) imidazo[2,1-b][1,3,4]thiadiazol-2′-yl}-sydnones 5h-5s were synthesized and screened for their anticancer and DNA cleavage activities and analyzed for pharmacological parameters such as toxicity, drug-likeliness, and drug score for oral bioavailability. In vitro toxicity assay was carried out by assessing the survival E. coli AB1157 (wild type) cultures. Some of the compounds have shown significant anticancer activities also.

Synthesis of 4-fluoromethylsydnones and their participation in alkyne cycloaddition reactions

We report the synthesis and some structural studies of 4-trifluoromethyl, 4-difluoromethyl-, and 4-monofluoromethylsydnones. All but the latter compounds are stable and represent effective precursors to a range of pyrazoles after cycloaddition reactions with alkynes. The cycloadditions are generally highly regioselective and provide 5-fluoromethylpyrazole products, although we have observed that Bn-substituted sydnones can provide an unexpected alkyne insertion mode that generates the 3-fluoromethyl isomer.

Regioselective reaction: Synthesis, characterization and pharmacological activity of some new Mannich and Schiff bases containing sydnone

A novel series of 1-substituted aminomethyl-3-[1-(4-isobutylphenyl)ethyl]- 4-(3-aryl-4-sydnonylidene) amino-1,2,4-triazol-5-thiones (9), was prepared from the 3-[1-(4-isobutylphenyl)ethyl]-4-(3-aryl-4-sydnonylidene) amino 5-mercapto-1,2,4-triazoles (8) by aminomethylation with formaldehyde and secondary amine. The structures of Schiff bases (8) and Mannich bases (9) were characterized on the basis of IR, NMR, mass spectra1 data and elemental analysis. The newly synthesized compounds were screened for their anti-inflammatory and analgesic activities. Mannich bases (9) carrying piperidine and morpholine residues showed promising anti-inflammatory and analgesic activity.

Synthesis of novel 2-(3′-aryl-sydnon-4′-ylidene)-5′- substituted-[1,3,4]-thiadiazolylamines and [1,3,4]-thiadiazol-2′-yl-3-oxo- [1,2,4]-triazoles as antimicrobial agents

The title compounds (3g-n) and (6g-n) were synthesized using 3-arylsydnones as synthons, and the structures were confirmed by IR, 1H NMR, FAB mass and CHN analysis. These compounds were evaluated for their antibacterial and the antifungal activ