1429500-40-2Relevant academic research and scientific papers
Discovery and optimization of pyrrolo[1,2-a]pyrazinones leads to novel and selective inhibitors of PIM kinases
Casuscelli, Francesco,Ardini, Elena,Avanzi, Nilla,Casale, Elena,Cervi, Giovanni,D'Anello, Matteo,Donati, Daniele,Faiardi, Daniela,Ferguson, Ronald D.,Fogliatto, Gianpaolo,Galvani, Arturo,Marsiglio, Aurelio,Mirizzi, Danilo G.,Montemartini, Marisa,Orrenius, Christian,Papeo, Gianluca,Piutti, Claudia,Salom, Barbara,Felder, Eduard R.
, p. 7364 - 7380 (2013/11/19)
A novel series of PIM inhibitors was derived from a combined effort in natural product-inspired library generation and screening. The novel pyrrolo[1,2-a]pyrazinones initial hits are inhibitors of PIM isoforms with IC50 values in the low microm
4-ALKYL SUBSTITUTED 3,4-DIHYDROPYRROLO[1,2-a]PYRAZIN-1(2H)-ONE DERIVATIVES AS KINASES INHIBITORS
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Page/Page column 49, (2013/04/24)
The present invention relates to 4-alkyl substituted 3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one derivatives which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such these compounds or the pharmaceutical compositions containing them
