1429500-40-2Relevant articles and documents
Discovery and optimization of pyrrolo[1,2-a]pyrazinones leads to novel and selective inhibitors of PIM kinases
Casuscelli, Francesco,Ardini, Elena,Avanzi, Nilla,Casale, Elena,Cervi, Giovanni,D'Anello, Matteo,Donati, Daniele,Faiardi, Daniela,Ferguson, Ronald D.,Fogliatto, Gianpaolo,Galvani, Arturo,Marsiglio, Aurelio,Mirizzi, Danilo G.,Montemartini, Marisa,Orrenius, Christian,Papeo, Gianluca,Piutti, Claudia,Salom, Barbara,Felder, Eduard R.
, p. 7364 - 7380 (2013/11/19)
A novel series of PIM inhibitors was derived from a combined effort in natural product-inspired library generation and screening. The novel pyrrolo[1,2-a]pyrazinones initial hits are inhibitors of PIM isoforms with IC50 values in the low microm