1429503-83-2

Upstream product

• 680227-80-9 [(S)-2-((S)-2-Cyano-pyrrolidin-1-yl)-1-(4-iodo-benzyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester 
• 1429503-68-3 C₂₄H₃₃N₃O₃Si 
• 1429504-08-4 C₂₁H₂₅N₃O₃ 
• 27032-10-6 4-chlorobenzyl azide 

Downstream Products

• 1429503-43-4 (S)-1-{(S)-2-amino-3-[4-(1-(4-chlorobenzyl)-1H-1,2,3-triazol-4-yl)phenyl]propanoyl}pyrrolidine-2-carbonitrile hydrochloride 

Relevant academic research and scientific papers

Synthesis and biological evaluation of novel benzyl-substituted (S)-phenylalanine derivatives as potent dipeptidyl peptidase 4 inhibitors

A series of novel benzyl-substituted (S)-phenylalanine derivatives were synthesized and evaluated for their dipeptidyl peptidase 4 (DPP-4) inhibitory activity and selectivity. It was found that most synthesized target compounds were potent DPP-4 inhibitors with IC50 values in 3.79-25.52 nM, which were significantly superior to that of the marketed drug sitagliptin. Furthermore, the 4-fluorobenzyl substituted phenylalanine derivative 6g not only displayed the potent DPP-4 inhibition with an IC50 value of 3.79 nM, but also showed better selectivity against DPP-4 over other related enzymes including DPP-7, DPP-8, and DPP-9. In an oral glucose tolerance test (OGTT) in normal Sprague Dawley rats, compound 6g reduced blood glucose excursion in a dose-dependent manner.