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1429503-90-1

tert-butyl {(S)-1-[(S)-2-cyanopyrrolidin-1-yl]-1-oxo-3-[4-(1-(pyridin-4-ylmethyl)-1H-1,2,3-triazol-4-yl)phenyl]propan-2-yl}carbamate is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • tert-butyl {(S)-1-[(S)-2-cyanopyrrolidin-1-yl]-1-oxo-3-[4-(1-(pyridin-4-ylmethyl)-1H-1,2,3-triazol-4-yl)phenyl]propan-2-yl}carbamate

    Cas No: 1429503-90-1

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  • 1429503-90-1 Structure

  • Basic information

    1. Product Name: tert-butyl {(S)-1-[(S)-2-cyanopyrrolidin-1-yl]-1-oxo-3-[4-(1-(pyridin-4-ylmethyl)-1H-1,2,3-triazol-4-yl)phenyl]propan-2-yl}carbamate
    2. Synonyms: tert-butyl {(S)-1-[(S)-2-cyanopyrrolidin-1-yl]-1-oxo-3-[4-(1-(pyridin-4-ylmethyl)-1H-1,2,3-triazol-4-yl)phenyl]propan-2-yl}carbamate
    3. CAS NO:1429503-90-1
    4. Molecular Formula:
    5. Molecular Weight: 501.588
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1429503-90-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: tert-butyl {(S)-1-[(S)-2-cyanopyrrolidin-1-yl]-1-oxo-3-[4-(1-(pyridin-4-ylmethyl)-1H-1,2,3-triazol-4-yl)phenyl]propan-2-yl}carbamate(CAS DataBase Reference)
    10. NIST Chemistry Reference: tert-butyl {(S)-1-[(S)-2-cyanopyrrolidin-1-yl]-1-oxo-3-[4-(1-(pyridin-4-ylmethyl)-1H-1,2,3-triazol-4-yl)phenyl]propan-2-yl}carbamate(1429503-90-1)
    11. EPA Substance Registry System: tert-butyl {(S)-1-[(S)-2-cyanopyrrolidin-1-yl]-1-oxo-3-[4-(1-(pyridin-4-ylmethyl)-1H-1,2,3-triazol-4-yl)phenyl]propan-2-yl}carbamate(1429503-90-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1429503-90-1(Hazardous Substances Data)

1429503-90-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1429503-90-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,2,9,5,0 and 3 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1429503-90:
(9*1)+(8*4)+(7*2)+(6*9)+(5*5)+(4*0)+(3*3)+(2*9)+(1*0)=161
161 % 10 = 1
So 1429503-90-1 is a valid CAS Registry Number.

1429503-90-1Relevant articles and documents

Synthesis and biological evaluation of novel benzyl-substituted (S)-phenylalanine derivatives as potent dipeptidyl peptidase 4 inhibitors

Liu, Yang,Si, Meimei,Tang, Li,Shangguan, Shihao,Wu, Haoshu,Li, Jia,Wu, Peng,Ma, Xiaodong,Liu, Tao,Hu, Yongzhou

, p. 5679 - 5687 (2013/09/12)

A series of novel benzyl-substituted (S)-phenylalanine derivatives were synthesized and evaluated for their dipeptidyl peptidase 4 (DPP-4) inhibitory activity and selectivity. It was found that most synthesized target compounds were potent DPP-4 inhibitors with IC50 values in 3.79-25.52 nM, which were significantly superior to that of the marketed drug sitagliptin. Furthermore, the 4-fluorobenzyl substituted phenylalanine derivative 6g not only displayed the potent DPP-4 inhibition with an IC50 value of 3.79 nM, but also showed better selectivity against DPP-4 over other related enzymes including DPP-7, DPP-8, and DPP-9. In an oral glucose tolerance test (OGTT) in normal Sprague Dawley rats, compound 6g reduced blood glucose excursion in a dose-dependent manner.

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