142952-69-0Relevant academic research and scientific papers
Synthesis and testing of new modified nucleosides
Jung, Michael E.,Nichols, Christopher J.,Kretschik, Oliver,Xu, Yue
, p. 541 - 546 (2007/10/03)
New efficient routes for the high-yielding synthesis of several classes of modified nucleosides have been developed. We have prepared both the D- and L-enantiomers of the methylene-expanded oxetanocin isonucleosides 1a-c and the L-2',3'-dideoxy isonucleosides 2abc (both the oxa and thia analogues) as well as new routes for the preparation of L-ribose and 2-deoxy L-ribose 3ab and their modified nucleosides 4.
Enantiospecific total synthesis of L-2',3'-dideoxyisonucleosides via regioselective opening of optically active C2-symmetric 1,4-pentadiene bis- epoxide
Jung,Kretschik
, p. 2975 - 2981 (2007/10/03)
A new method for the synthesis of L-2',3'-dideoxyisonucleosides is described. The readily available, optically active C2-symmetric bis-epoxide (2S,4S)-1,2:4,5-diepoxypentane (5) was prepared by a short route from readily available starting mate
Enantiospecific Synthesis of 3'-Hetero-dideoxy Nucleoside Analogues as Potential Anti-HIV Agents
Jones, Martin F.,Noble, Stewart A.,Robertson, Colin A.,Storer, Richard,Highcock, Rona M.,Lamont, R. Brian
, p. 1427 - 1436 (2007/10/02)
Two series of analogues of 2',3'-dideoxy carbocyclic nucleosides, in which the 3'-carbon atom is replaced by either an oxygen or a sulfur atom, have been prepared enantiospecifically from diacetone-L-glucose and diacetone-D-glucose respectively.Within eac
TETRAHYDROTHIOPHENE NUCLEOSIDES AS POTENTIAL ANTI-HIV AGENTS
Jones, Martin F.,Noble, Stewart A.,Robertson, Colin A.,Storer, Richard
, p. 247 - 250 (2007/10/02)
A series of novel tetrahydrothiophene nucleosides have been prepared in homochiral form from D-glucose and assessed as anti-HIV agents in whole cell assay.
