1429656-49-4

Upstream product

• 108-98-5 thiophenol 
• 200803-17-4 rac-2-(2-bromophenyl)-1-tosylaziridine 

Downstream Products

• 1429656-41-6 3-(phenylthio)-1-tosylindoline 
• 31271-90-6 1-(p-toluenesulfonyl)-1H-indole 

Relevant academic research and scientific papers

A Synthetic Route to 2-Alkyl Indoles via Thiophenol-Mediated Ring-Opening of N-Tosylaziridines Followed by Copper Powder-Mediated C-N Cyclization/Aromatization

A simple strategy for the syntheses of 2-alkyl indoles via regioselective ring-opening of 2-(2-haloaryl)-3-alkyl-N-tosylaziridines with thiophenol, followed by copper powder-mediated intramolecular C-N cyclization and subsequent aromatization by the elimi

Synthetic route to chiral indolines via ring-opening/C-N cyclization of activated 2-haloarylaziridines

A practical approach for the synthesis of 3-substituted indolines via regio- and stereoselective SN2-type ring-opening of 2-(2-halophenyl)-N-tosylaziridines with heteroatomic nucleophiles (O, N, and S) followed by palladium-catalyzed intramolecular C-N cyclization is reported in excellent yields (up to >99%) and enantiomeric excess (ee 99%).