142977-81-9Relevant academic research and scientific papers
Degradation kinetics and mechanisms of moricizine hydrochloride in acidic medium
King,Sigvardson,Dudzinski,Torosian
, p. 586 - 591 (2007/10/02)
The degradation kinetics of moricizine hydrochloride (1) were examined over a pH range of 0.6 to 6.0 at an ionic strength of 0.3 and 60 °C. The disappearance of intact 1 was followed by a stability-indicating HPLC assay. The degradation products, which had approximate solubilities of 2.8. At pH >4.0, the reverse Mannich product was the predominant degradation product. Degradation of 1 was subject to positive and negative kinetic salt effects at pH 1.0 and 4.0, respectively. Arrhenius plots determined at pH 1.0 and 6.0 were linear between 37 and 70 °C. Predicted shelf lives at room temperature (22 °C) at pH 1.0 and 6.0 were identical to the shelf lives determined experimentally.
