29560-58-5 Usage
Uses
Used in Pharmaceutical Industry:
Moricizine Hydrochloride is used as a cardiac depressant (anti-arrhythmic) for treating life-threatening ventricular arrhythmias. It is effective in suppressing premature ventricular contractions, couplets, and nonsustained ventricular tachycardia. Its narrow indication reflects its proarrhythmic potential, but the incidence of this adverse reaction is lower than that of other antiarrhythmic agents.
Used in Cardiology:
Moricizine Hydrochloride is used as an antiarrhythmic agent in the field of cardiology. It helps in managing and treating specific types of heart rhythm disorders, providing relief to patients suffering from these conditions.
Brand Name:
Ethmozine (Shire) is the brand name under which Moricizine Hydrochloride is marketed.
Originator
Acad. Med. Sci. (USSR)
Manufacturing Process
To a solution of 10 g (0.035 mole) of ethyl phenthiazine-2-carbamate in 30 ml
of anhydrous toluene is added dropwise 5.3 g (0.042 mole) of 3-
chloropropionyl chloride, and the mixture is refluxed at 110-120°C for 4
hours, followed by clarifying the mixture with activated carbon and cooling it
to room temperature. A precipitate of ethyl 10-(3-chloropropionyl)-
phenthiazine-2-carbamate is removed by filtration. The yield is 10.2 g (77.5%
of the theoretical amount), M.P. 169-170°C.10.2 g of ethyl 10-(3-chloropropionyl)-phenthiazine-2-carbamate ester is
dissolved in 50 ml of toluene, 4.72 g of morpholine is added thereto, and the
mixture is refluxed at 110-120°C for a period of 3 hours. A precipitate of
morpholine hydrochloride is removed by filtration, and the filtrate is washed
with water in order to remove excess morpholine, followed by acidulating with
dilute hydrochloric acid to adjust the pH of the filtrate is adjusted at 3. The
acidic aqueous layer is separated, clarified by treatment with activated carbon
and made alkaline until the pH equals 8-9. This procedure yields the free base
of ethyl 10-(β-morpholylpropionyl)-phenthiazine-2-carbamate, M.P. 156-
157°C.The free base thus obtained is extracted with toluene, the extract is dried over
magnesium sulphate and to the anhydrous toluene solution is added an
anhydrous ethereal solution of hydrogen chloride until the precipitation of the
target compound is complete. This procedure yields 9.53 g (76.2% of the
theoretical amount) of ethyl 10-(β-morpholylpropionyl)-phenthiazine-2-
carbamate hydrochloride. After recrystallization from dichloroethane, the
target compound melts at 189°C. (decomp.).
Therapeutic Function
Antiarrhythmic
Check Digit Verification of cas no
The CAS Registry Mumber 29560-58-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,9,5,6 and 0 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 29560-58:
(7*2)+(6*9)+(5*5)+(4*6)+(3*0)+(2*5)+(1*8)=135
135 % 10 = 5
So 29560-58-5 is a valid CAS Registry Number.
InChI:InChI=1/C22H25N3O4S.ClH/c1-2-29-22(27)23-16-7-8-20-18(15-16)25(17-5-3-4-6-19(17)30-20)21(26)9-10-24-11-13-28-14-12-24;/h3-8,15H,2,9-14H2,1H3,(H,23,27);1H
