1429920-35-3Relevant academic research and scientific papers
Total synthesis of the escherichia coli O111 O-specific polysaccharide repeating unit
Calin, Oliviana,Eller, Steffen,Hahm, Heung Sik,Seeberger, Peter H.
supporting information, p. 3995 - 4002 (2013/04/24)
The first total synthesis of the O-antigen pentasaccharide repeating unit from Gram-negative bacteria Escherichia coli O111 was achieved starting from four monosaccharide building blocks. Key to the synthetic approach was a bis-glycosylation reaction to combine trisaccharide 10 and colitose 5. The colitose building block (5) was obtained de novo from non-carbohydrate precursors. The pentasaccharide was equipped at the reducing end with an amino spacer to provide a handle for subsequent conjugation to a carrier protein in anticipation of immunological studies. Killing them sweetly: As a first step towards diagnostics and vaccines to detect and prevent serious infections with Escherichia coli bacteria, the pentasaccharide repeating unit from the O-antigen of E. coli O111 was synthesized. Copyright
