1429933-67-4

Upstream product

• 137-07-5 2-amino-benzenethiol 
• 619-41-0 4-(bromoacetyl)toluene 
• 19195-31-4 3-(4'-methylphenyl)-2H-1,4-benzothiazine 

Downstream Products

• 1429933-82-3 (S)-3-(p-tolyl)-3,4-dihydro-2H-benzo[b][1,4]thiazin-2-one 

Relevant academic research and scientific papers

Metal-free sp3 C-H bond oxidation and functionalization of α-bromoketones to quinoxalinone, benzoxazinone, and benzothiazinone heterocyclic compounds

A series of heterocyclic compounds (benzothiazinones, benzoxazinones and quinoxalinones) were efficiently synthesized in excellent yields via α-bromoketones with o-substituted aniline (2-aminothiophenol, aryl-1,2-diamines and 2-aminophenol). This protocol accomplishes sp3 C-H bond oxidation and functionalization in one-pot without any metal catalyst.

An efficient synthetic protocol for quinoxalinones, Benzoxazinones, and benzothiazinones from 2-oxo-2-aryl-acetyl bromide precursors

α-Bromoketones undergo selenium dioxide oxidation to yield reactive 2-oxo-2-arylacetyl bromides that are trapped by aryl-1,2-diamines, 1,2-aminophenol or 1,2-aminothiophenol to give quinoxalinones, benzoxazinones, and benzothiazinones, respectively, in go

[Ir(P-OP)]-catalyzed asymmetric hydrogenation of diversely substituted C=N-containing heterocycles

Iridium(I) complexes of enantiomerically pure phosphine-phosphite ligands ([Ir(Cl)(cod)(P - OP)]) efficiently catalyze the enantioselective hydrogenation of diverse C=N-containing heterocyclic compounds (benzoxazines, benzoxazinones, benzothiazinones, and quinoxalinones; 25 examples, up to 99% ee). A substrate-to-catalyst ratio as high as 2000:1 was reached.