142994-01-2

Basic information

• Product Name: 5-Bromo-2-methylthioanisole
• Synonyms: 5-Bromo-2-methylthioanisole
• CAS NO: 142994-01-2
• Molecular Formula: C₈H₉BrS
• Molecular Weight: 217.12606
• Mol File: 142994-01-2.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-Bromo-2-methylthioanisole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromo-2-methylthioanisole(142994-01-2)
• EPA Substance Registry System: 5-Bromo-2-methylthioanisole(142994-01-2)

Safety Data

• Hazardous Substances Data: 142994-01-2(Hazardous Substances Data)

Upstream product

• 98594-08-2 4-methyl-3-(methylsulphenyl)aniline 
• 7787-70-4 copper(I) bromide 
• 51436-99-8 2-fluoro-4-bromotoluene 
• 5188-07-8 sodium thiomethoxide 
• 1093847-06-3 S-5-bromo-2-methylphenyl O-ethylcarbonodithioate 
• 69321-55-7 5-bromo-2-methylbenzenethiol 
• 74-88-4 methyl iodide 
• 60956-26-5 4-bromo-2-nitrotoluene 

Downstream Products

• 1346819-66-6 C₁₃H₁₅BrO₆S 
• 773873-27-1 (4-bromo-2-(methylsulfonyl)phenyl)methanol 
• 152595-59-0 1,2-dihydro-4-[(4-methylthiophenyl)-methyl]-5-trifluoromethyl-3H-pyrazol-3-one 

Relevant articles and documents

Subtle "supramolecular buttressing effects" in Cucurbit[7]uril/guest assemblies

Biphenyl derivatives bearing a dimethylsulfonium group at position 3 and three different substituents at position 4 (H, F and CH3) have been prepared as probes to test the validity of the "supramolecular buttressing" concept. We define the latter as the alteration, by a neighboring unit, of a substituent effect on intermolecular recognition. In this case, the 4-substituents exert some pressure on the 3-dimethylsulfonium groups and control the ratio of their syn and anti conformations. As free species, biphenyls bearing 4-H and 4-F substituents are present as approximately equimolar mixtures of syn and anti-conformers, while the biphenyl scaffold with a 4-CH3 group adopts the anti-conformation exclusively. The 3-dimethylsulfonium substituents then interact with one of the carbonylated portals of Cucurbit[7]uril (CB[7]), and their conformations affect the position of the guests inside the cavity of the macrocycle, thereby validating our "supramolecular buttressing" model. Surprisingly however, binding affinities towards CB[7] are barely affected by the nature of the 4-substituents and the conformations of the neighboring sulfonium groups, despite very different electronic densities presented to the CB[7] portal in their syn or anti conformations. Solvation was found to dramatically smoothen host-guest Columbic interactions, although the latter remain important in the recognition process. Replacing the positively charged 3-dimethylsulfonium unit with an isopropyl substituent decreases the affinity of the biphenyl guest by 1000-fold. The Royal Society of Chemistry 2013.

DIARYL KETIMINE DERIVATIVE HAVING ANTAGONISM AGAINST MELANIN-CONCENTRATING HORMONE RECEPTOR

[Problems] To provide an antagonist of a melanin-concentrating hormone receptor, which is useful as a medicine for a central nervous system disease, a cardiovascular disease or a metabolic disease. [Means for Solving Problems] The antagonist comprises, as an active ingredient, a compound represented by the formula (I) wherein R1a and R1b independently represent a hydrogen atom or a C1-6 alkyl group; R2a, R2b, R3a and R3b independently represent a hydrogen atom, a C1-6 alkyl group, or the like; Y represents H or —OH; Z represents —OR8, or the like; R8 represents a hydrogen atom, a C1-6 alkyl group which may have a substituent, or the like; R9a and R9b independently represent a hydrogen atom, a C1-6 alkyl group, or the like; Ar1 represents an aromatic carbon ring group, or an aromatic heteroring group; Ar2 represents a group produced by removing two hydrogen atoms from an aromatic carbon ring, or the like; and the ring group A represents an unsaturated heteroring group.

Herbicidal 2-cyano-1,3-diones

Herbicides derived from 2-cyano-1,3-diones have the formula: STR1 wherein R, R1, R2 R3, R4 and R5 are as defined in the description. The compounds are intended for use pre- and post-emergence as selective herbicides in maize and a large number of other monocotyledon crops.