143-09-9Relevant articles and documents
Synthesis, Characterization, Surface, and Thermodynamic Studies of Alkyl Tetrachloroferrates: Performance Evaluation of Their Nanostructures as Biocides
El-Shamy, Omnia A. A.,Habib, Amr O.,Mohamed, Dalia E.,Badawi, Abdelfattah M.
, p. 215 - 223 (2020)
Decyl and dodecylamino tetrachloroferrates were synthesized and characterized using Fourier-transform infrared spectroscopy (FTIR), elemental analysis, X-ray diffraction (XRD), nuclear magnetic resonance (1H-NMR), and atomic absorption spectroscopy (AAS). The surface properties of the cationic surfactants including critical micelle concentration, effectiveness, minimum surface area, and maximum surface excess were determined using surface tension measurements. The effectiveness of surface tension reduction (πcmc) was found to increase as the hydrophobic chain length increases with values of 30 and 34 mN m?1 for C10 and C12, respectively. Moreover, the effect of temperature on micellization was determined over the range of 35–55?°C. Thermodynamic parameters (ΔG°, ΔS°, and ΔH°) were calculated and the results indicate a spontaneous process for both micellization and adsorption. The nanoparticles (NC10 and NC12) of the prepared surfactants were obtained using the ball mill technique. The particle size and morphology of the nanoparticles were determined using transmission electron microscope measurements. The antibacterial study of the nanoparticle surfactants revealed their strong efficiency against fungi and different pathogenic bacteria compared with the original surfactants.
Synthesis of Molybdenum Pincer Complexes and Their Application in the Catalytic Hydrogenation of Nitriles
Leischner, Thomas,Spannenberg, Anke,Junge, Kathrin,Beller, Matthias
, p. 4543 - 4549 (2020/07/13)
A series of molybdenum(0), (I) and (II) complexes ligated by different PNP and NNN pincer ligands were synthesized and structurally characterized. Along with previously described Mo?PNP complexes Mo-1 and Mo-2, all prepared compounds were tested in the catalytic hydrogenation of aromatic nitriles to primary amines. Among the applied catalysts, Mo-1 is particularly well suited for the hydrogenation of electron-rich benzonitriles. Additionally, two aliphatic nitriles were transformed into the desired products in 80 and 86 percent, respectively. Moreover, catalytic intermediate Mo-1a was isolated and its role in the catalytic cycle was subsequently demonstrated.
Designing Simple Lipidated Lysines: Bifurcation Imparts Selective Antibacterial Activity
Ghosh, Chandradhish,Konai, Mohini Mohan,Sarkar, Paramita,Samaddar, Sandip,Haldar, Jayanta
supporting information, p. 2367 - 2371 (2016/11/13)
In the global effort to thwart antimicrobial resistance, lipopeptides are an important class of antimicrobial agents, especially against Gram-negative infections. In an attempt to circumvent their synthetic complexities, we designed simple membrane-active agents involving only one amino acid and two lipid tails. Herein we show that the use of two short lipid tails instead of a single long one significantly increases selective antibacterial activity. This study yielded several selective antibacterial compounds, and investigations into the properties of this compound class were conducted with the most active compound. Fluorescence spectroscopic studies revealed the capacity of the representative compound to cause depolarization and permeabilization of bacterial cell membranes. This membrane-active nature of the compound imparts superior activity against persister cells, biofilms, and planktonic cells. Topical application of the compound decreased bacterial burden in mice inflicted with burn-infections caused by Acinetobacter baumannii. We anticipate that the design principles described herein will direct the development of several antimicrobial agents of clinical importance.
