4385-04-0

Basic information

• Product Name: N,N-DIMETHYLHEXYLAMINE
• Synonyms: N-(N-HEXYL)DIMETHYLAMINE;N,N-DIMETHYLHEXYLAMINE;1-(DIMETHYLAMINO)HEXANE;1-Hexanamine, N,N-dimethyl-;Hexanamine, N,N-dimethyl;N,N-Dimethyl-1-hexanamine;N,N-Dimethyl-n-hexylamine;N,N-Dimethylhexylamine,99%
• CAS NO: 4385-04-0
• Molecular Formula: C₈H₁₉N
• Molecular Weight: 129.24
• EINECS: 224-491-8
• Product Categories: Amines;C8;Nitrogen Compounds
• Mol File: 4385-04-0.mol
• Article Data: 43

Chemical Properties

• Melting Point: -76.53°C (estimate)
• Boiling Point: 146-150 °C(lit.)
• Flash Point: 92 °F
• Appearance: Clear colorless/Liquid
• Density: 0.744 g/mL at 25 °C(lit.)
• Vapor Pressure: 4.49mmHg at 25°C
• Refractive Index: n20/D 1.414(lit.)
• Storage Temp.: Flammables area
• Solubility: Miscible with methanol.
• PKA: 9.99±0.28(Predicted)
• Stability: Stable. Flammable. Incompatible with strong acids, strong oxidizing agents.
• BRN: 1732757
• CAS DataBase Reference: N,N-DIMETHYLHEXYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-DIMETHYLHEXYLAMINE(4385-04-0)
• EPA Substance Registry System: N,N-DIMETHYLHEXYLAMINE(4385-04-0)

Safety Data

• Hazard Codes: C
• Statements: 10-34
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 2733 3/PG 3
• WGK Germany: 3
• F: 9
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 4385-04-0(Hazardous Substances Data)

Usage

Chemical Properties

colourless liquid

Uses

Different sources of media describe the Uses of 4385-04-0 differently. You can refer to the following data:
1. N,N-Dimethylhexylamine is used as an ion-pairing agent to study the poor retention of uridine diphosphate-linked intermediates on reverse phase media. It is also used in the determination of five monophosphate nucleotides in baby foods. It acts as an additive and encapsulated into the nanoparticle with salinomycin (sali), which has selective toxicity to cancer stem cells.
2. N,N-Dimethylhexylamine was used as ion-pairing agent to study the problem of poor retention of uridine diphosphate-linked intermediates on reverse phase media. It was also used in the determining the five monophosphate nucleotides (cytidine 5′-monophosphate, uridine 5′-monophosphate, adenosine 5′-monophosphate, inosine 5′-monophosphate and guanosine 5′-monophosphate) in baby foods.

Synthesis Reference(s)

Synthesis, p. 996, 1981 DOI: 10.1055/s-1981-29677

General Description

The free Salinomycin (Sali), that has selective toxicity to cancer stem cells (CSCs), was encapsulated into the nanoparticle along with the additive N,N-dimethylhexylamine.

InChI:InChI=1/C8H19N/c1-4-5-6-7-8-9(2)3/h4-8H2,1-3H3/p+1

Upstream product

• 50-00-0 formaldehyd 
• 64-18-6 formic acid 
• 7334-95-4 n-hexylammonium bromide 
• 111-26-2 hexan-1-amine 
• 2650-53-5 n-hexyltrimethylammonium bromide 
• 111-25-1 1-bromo-hexane 
• 124-38-9 carbon dioxide 
• 646-14-0 1-nitrohexane 
• 67-56-1 methanol 
• 6926-45-0 1-azidohexane 
• 124-40-3 dimethyl amine 
• 111-27-3 hexan-1-ol 
• 142-61-0 Hexanoyl chloride 
• 5830-30-8 N,N-dimethylhexanamide 

Downstream Products

• 131409-91-1 hexyl-dimethyl-(2-phenoxy-ethyl)-ammonium; bromide 
• 1234679-35-6 Br^(1-)*C₂₈H₃₉N₂O₃⁽¹⁺⁾ 
• 1234679-42-5 Br^(1-)*C₃₂H₄₇N₂O₃⁽¹⁺⁾ 
• 15066-77-0 n-Hexyltrimethylammonium iodide 

Relevant articles and documents

Green and chemo selective amine methylation using methanol by an organometallic ruthenium complex

Herein a green and convenient catalytic N-methylation of aniline and n-hexylamine using methanol as a dual methylation agent and solvent has been investigated. A new ruthenium carbonyl complex was synthesized and applied as a homogeneous catalyst in methylation reaction. The solid-state structure of the complex was determined by X-ray crystallographic analysis which indicate xantphos ligand bonded to ruthenium (II) as a tridentate pincer ligand by two P donor and one O atom. The catalytic system showed excellent conversion and selectivity toward N-methylaniline, and N,N-hexyldimethylamine at 140°C.

Deoxygenative hydroboration of primary, secondary, and tertiary amides: Catalyst-free synthesis of various substituted amines

Transformation of relatively less reactive functional groups under catalyst-free conditions is an interesting aspect and requires a typical protocol. Herein, we report the synthesis of various primary, secondary, and tertiary amines through hydroboration of amides using pinacolborane under catalyst-free and solvent-free conditions. The deoxygenative hydroboration of primary and secondary amides proceeded with excellent conversions. The comparatively less reactive tertiary amides were also converted to the corresponding N,N-diamines in moderate yields under catalyst-free conditions, although alcohols were obtained as a minor product.

Method for preparing tertiary amine organic compound by decomposing substituted formamide under mild condition

The invention discloses a method for preparing tertiary amine organic compounds by decomposing substituted formamide under mild conditions, which comprises the following steps: heating and stirring aldehydes serving as a reaction substrate, substituted formamide serving as a solvent, a reducing agent and an amination reagent, Ti-based oxide/hydroxide serving as a catalyst and a small amount of water serving as an auxiliary agent to generate the corresponding tertiary amine compound. Hydrogen is not needed in the reaction process. The method can be suitable for various aldehydes including aromatic aldehydes, fatty aldehydes and the like, and has the characteristics of high conversion rate and single product, and the tertiary amine compound can be simply, efficiently and safely synthesized without using hydrogen and noble metals in the reaction, so that the method has remarkable economic effects and application prospects.