143005-71-4

Basic information

• Product Name: (S)ethyl-2-hexan-1-ol (R)-<2-methoxy-2-phenyl-2-(trifluoromethyl)acetic> ester
• CAS NO: 143005-71-4
• Molecular Weight: 346.39
• Mol File: 143005-71-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (S)ethyl-2-hexan-1-ol (R)-<2-methoxy-2-phenyl-2-(trifluoromethyl)acetic> ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)ethyl-2-hexan-1-ol (R)-<2-methoxy-2-phenyl-2-(trifluoromethyl)acetic> ester(143005-71-4)
• EPA Substance Registry System: (S)ethyl-2-hexan-1-ol (R)-<2-methoxy-2-phenyl-2-(trifluoromethyl)acetic> ester(143005-71-4)

Safety Data

• Hazardous Substances Data: 143005-71-4(Hazardous Substances Data)

Upstream product

• 128821-84-1 (S)-(+)-2-ethylhexan-1-ol 
• 20445-31-2 R-(+)-α-trifluoromethyl-α-methoxy-phenylacetic acid 
• 39637-99-5 (S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride 
• 72377-05-0 (2S)-ethylhexanoic acid 
• 951328-09-9 (1R,2R)-(-)-pseudoephedrine-2S-ethylhexamide 
• 50373-28-9 (S)-2-ethylhexyl acetate 
• 104-76-7 2-Ethylhexyl alcohol 

Relevant articles and documents

Synthesis and biochemical evaluation of highly enantiomerically pure (R,R)- and (S,S)-alexidine

Alexidine is in everyday human use as oral disinfectant and contact lens disinfectant. It is used as a mixture of stereoisomers. Since all of alexidine's known biological targets are chiral, the biological activity of any of its chiral stereoisomers could be significantly higher than that of the mixture of stereoisomers. This makes a synthetic methodology for obtaining the individual enantiomers of the chiral diastereoisomer highly desirable. Here, we describe the first synthesis of both enantiomers of alexidine in high enantiomeric purity, and demonstrate their activity against the protein-protein interaction between the anti-apoptotic protein Bcl-xL and the pro-apoptotic protein Bak.