1430074-84-2Relevant academic research and scientific papers
Diiodine-Mediated Oxidative Reaction for the Construction of Imidazo[1,5- a ]pyridines under Metal-Free Conditions
Chen, Baohua,Chen, Yongxin,Liu, Yafeng,Qin, Mingda,Su, Kexin,Tian, Yuan
supporting information, p. 695 - 698 (2020/04/08)
An efficient and general protocol has been developed for preparing imidazo[1,5- a ]pyridines in moderate to excellent yields by an I 2 -mediated sequential dual oxidative C(sp 3)-H amination of ethyl pyridin-2-ylacetates with benzylamines. The metal- and peroxide-free reaction involves oxidative dehydrogenation and two C-N couplings.
Metal-free synthesis of imidazo[1,5- a] pyridines via elemental sulfur mediated sequential dual oxidative Csp3-H amination
Sheng, Jie,Liu, Jidan,Zhao, He,Zheng, Liyao,Wei, Xingchuan
supporting information, p. 5570 - 5574 (2018/08/17)
A simple and efficient approach has been developed for the synthesis of imidazo[1,5-a]pyridines using the elemental sulfur mediated sequential dual oxidative Csp3-H amination of 2-pyridyl acetates and amines under metal- and peroxide-free conditions. Broad substrate scope, operational simplicity and gram-scale ability make this chemistry very practical.
Copper-catalyzed denitrogenative transannulation reaction of pyridotriazoles: Synthesis of imidazo[1,5-a]pyridines with amines and amino acids
Joshi, Abhisek,Chandra Mohan, Darapaneni,Adimurthy, Subbarayappa
supporting information, p. 464 - 467 (2016/02/18)
The copper-catalyzed aerobic oxidative synthesis of imidazo[1,5-a]pyridines via cascade denitrogenative transannulation reaction of pyridotriazoles with benzylamines with good functional group tolerance is developed. The present methodology is also applicable to amino acids to obtain imidazo[1,5-a]pyridines via decarboxylative oxidative cyclization.
Design, synthesis and biological evaluation of imidazo[1,5-a]pyridine-PBD conjugates as potential DNA-directed alkylating agents
Kamal, Ahmed,Ramakrishna,Ramaiah, M. Janaki,Viswanath,Rao, A. V. Subba,Bagul, Chandrakant,Mukhopadyay, Debasmitha,Pushpavalli,Pal-Bhadra, Manika
, p. 697 - 703 (2013/06/05)
A series of novel imidazo[1,5-a]pyridine-PBD conjugates were synthesized and evaluated for their antitumor activity in breast cancer cell line (MCF-7). Interestingly, all the compounds showed enhanced DNA binding ability. These conjugates showed significa
Mild metal-free sequential dual oxidative amination of C(sp3)-H bonds: Efficient synthesis of imidazo[1,5-a]pyridines
Yan, Yizhe,Zhang, Yonghui,Zha, Zhenggen,Wang, Zhiyong
, p. 2274 - 2277 (2013/06/05)
A metal-free sequential dual oxidative amination of C(sp3)-H bonds under ambient conditions was the first developed, affording imidazo[1,5-a]pyridines in good to excellent yields. The reaction was involved in two oxidative C-N couplings and one oxidative dehydrogenation process with six hydrogen atoms removed.
