1430092-75-3Relevant articles and documents
Synthesis and biological evaluation of 1,3,4-thiadiazole analogues as novel AChE and BuChE inhibitors
Skrzypek, Alicja,Matysiak, Joanna,Niewiadomy, Andrzej,Bajda, Marek,Szymanski, Pawel
, p. 311 - 319 (2013/05/09)
In this paper a series of new 1,3,4-thiadiazole derivatives has been designed, synthesized and evaluated as the acetyl- and butyrylcholinesterase inhibitors. Some analogues showed promising inhibition of both enzymes in vitro in the nM range. Generally, i