14302-75-1Relevant academic research and scientific papers
Multiple metal coordinating behaviour of the tetrapodal ligand 1,1,1,1-tetrakis[(salicylaldimino)methyl]methane
Dutta, Supriya,Biswas, Papu,Fl?rke, Ulrich,Nag, Kamalaksha
, p. 1074 - 1080 (2010)
The tetrapodal ligand 1,1,1,1-tetrakis[(salicylaldimino)methyl]methane (H4tsam) has been introduced for the first time for metal complexation. Two zinc(II) complexes[Zn2(tsam)] (1) and [Zn 3(Htsam)2]?2C7H8 (2) have been obtained by reacting zinc acetylacetonate with the ligand in the presence of triethylamine, while a cobalt(III) complex [Co(Htsam)]?CH 3CN?H2O (3) is obtained when Co(ClO4) 2?6H2O is reacted in air. All the compounds have been characterized by their elemental analyses and ESI-MS, IR, UV-VIS and 1H NMR spectra. The X-ray crystal structures of H4tsam, 2 and 3 have been determined. Compounds 1 and 2 exhibit fluorescence in solution and the lifetimes of their luminescence decay have been measured. Thermal analysis (TGA, DTA) of 2 with regard to loss of encapsulated toluenes and redox behaviour of 3 have been studied.
An efficient synthesis of D-galactose-based multivalent neoglycoconjugates
De Andrade, Saulo F.,Figueiredo, Rute C.,De Souza Filho, Jose? D.,Alves, Ricardo J.
experimental part, p. 1062 - 1069 (2012/09/10)
In this work, the synthesis of dimeric, trimeric and tetrameric D-galactose-based neoglycoconjugates is reported. The monosaccharide ligand was prepared in 5 straightforward steps from D-galactose using the Doebner modification of the Knoevenagel reaction for chain elongation. The ligand was coupled to 1,4-butanediamine, tris-(2-ethylamino)amine, pentaerythrityltetramine and PAMAM dendrimers (1,4-butanodiamine core G0 and 1,12-dodecanediamine core G0). The unprotected glycodendrimers were purified by size-exclusion chromatography (SEC). This was the only step in which a chromatographic method was employed throughout the synthetic route. This is a new and efficient strategy for the preparation of neoglycoconjugates.
