1430203-74-9Relevant academic research and scientific papers
Three-component condensation of 1,3-dimethyl-barbituric acid, arylglyoxals, and substituted thioureas
Kolos,Zamigailo,Chechina,Omel'Chenko,Shishkin,Vashchenko
, p. 1817 - 1823 (2013)
4-Aryl-2-methylaminothiazoles and 5-aryl-2-mercapto-1-methylimidazoles, containing a fragment of 1,3-dimethylbarbituric acid, have been synthesized by the one-pot three-component condensation of 1,3-dimethylbarbituric acid, arylglyoxal hydrates, and N-methylthiourea. The analogous reaction involving N-arylthioureas proceeds regioselectively with the formation of 4-aryl-2-arylaminothiazoles. It was established that in the crystalline state 5-aryl-2-mercaptoimidazoles exist in the imidazoline-2-thione form.
