598-52-7

Basic information

• Product Name: N-METHYLTHIOUREA
• Synonyms: 1-METHYLTHIOUREA;1-METHYL-2-THIOUREA;METHYLTHIOUREA;METU;N-METHYLTHIOUREA;N-METHYLTHLOUREA;MTH;1-methyl-2-thio-pseudoure
• CAS NO: 598-52-7
• Molecular Formula: C₂H₆N₂S
• Molecular Weight: 90.15
• EINECS: 209-936-6
• Product Categories: Organic Building Blocks;Sulfur Compounds;Thioureas;N-METHYLTHIOUREA ada@tuskwei.com
• Mol File: 598-52-7.mol
• Article Data: 21

Chemical Properties

• Melting Point: 118-121 °C(lit.)
• Boiling Point: 141.082 °C at 760 mmHg
• Flash Point: 39.126 °C
• Appearance: White to light yellow/Crystalline Powder
• Density: 1.095 (estimate)
• Vapor Pressure: 5.95mmHg at 25°C
• Refractive Index: 1.5300 (estimate)
• Storage Temp.: Store below +30°C.
• PKA: 14.98±0.70(Predicted)
• Water Solubility: Soluble in water
• BRN: 506162
• CAS DataBase Reference: N-METHYLTHIOUREA(CAS DataBase Reference)
• NIST Chemistry Reference: N-METHYLTHIOUREA(598-52-7)
• EPA Substance Registry System: N-METHYLTHIOUREA(598-52-7)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 36/37/39-45
• RIDADR: UN 2811 6.1/PG 2
• WGK Germany: 3
• RTECS: YT9000000
• HazardClass: 6.1
• PackingGroup: II
• Hazardous Substances Data: 598-52-7(Hazardous Substances Data)

Usage

Chemical Properties

white to light yellow crystalline powder

InChI:InChI=1/C2H6N2S/c1-4-2(3)5/h1H3,(H3,3,4,5)

Upstream product

• 460-19-5 ethanedinitrile 
• 534-13-4 N,N-dimethylthiourea 
• 37929-27-4 1,4,4,6-tetramethyl-1,4-dihydropyrimidine-2(3H)-thione 
• 75039-91-7 ethyl 3-(N-methylcyanamino)-2-butenoate 
• 38475-06-8 N,N''-dimethyl-μ-disulfido-dicarboxamidine 
• 6317-20-0 2,4-dimethyl-1,2,4-thiadiazolidine-3,5-dithione 
• 7664-41-7 ammonia 
• 64-17-5 ethanol 
• 13037-11-1 S-methyl N-methyl dithiocarbamate 
• 625-57-0 O-ethyl thiocarbamate 
• 7732-18-5 water 
• 74-89-5 methylamine 
• 16486-25-2 1-benzoyl-3-methyl-thiourea 
• 39713-76-3 methyl dithiocarbamic acid triethylammonium 

Downstream Products

• 108989-45-3 5-hydroxy-2-(methylcarbamimidoylmercapto-methyl)-pyran-4-one; hydrochloride 
• 33860-39-8 6-benzoyl-2-methylamino-5,6-dihydro-4H-thiazolo[4,5-e]indole 
• 26269-12-5 5-Hydroxy-2-methylamino-4-methylnaphtho<1,2-d>thiazole 
• 57518-11-3 (3-methylamino-4-o-tolyl-4H-[1,2,4]thiadiazol-5-ylidene)-o-tolyl-amine 
• 96365-56-9 17α-hydroxy-17β-(2-methylamino-thiazol-4-yl)-androst-4-en-3-one 
• 96262-20-3 17α-hydroxy-17β-(2-methylamino-thiazol-4-yl)-androst-4-ene-3,11-dione 
• 71535-31-4 N¹-methyl-2,5-diphenyl-Δ²-1,3,4-thiadiazoline-4-carboxamidine 
• 95440-99-6 17ss-<2-Methylamino-thiazolyl-(4)>-androsten-(4)-on-(3) 
• 46341-34-8 Bis--sulfid 
• 37760-35-3 1-(2-methylamino-4-phenyl-thiazol-5-yl)-pyridinium; bromide 
• 30213-03-7 1-(6-chloro-3-cyclohexyl-2-oxo-3,4-dihydro-2H-benzo[e][1,3]oxazin-4-yl)-3-methyl-thiourea 
• 3305-93-9 Kohlensaeure-p-tolylester-imid-methylcyanamid 
• 1126-82-5 O-(4-methyl)phenyl thiocarbamate 
• 2933-32-6 2-(methylamino)-5-phenyl-1,3-thiazol-4(5H)-one 

Relevant articles and documents

Liquid chromatographic determination of noxytiolin and 1-methyl-2-thiourea in serum: Application to pharmacokinetic studies in rabbits and humans

A high-performance liquid chromatographic method is described which determines noxytiolin and 1-methyl-2-thiourea concentrations in serum. Valid determination requires immediate ultracentrifugation of blood samples, rapid serum freezing, and injection into the chromatograph within 6 h. A number of pharmacokinetic parameters were calculated from serum concentration data in rabbits and humans. An unknown metabolite was detected in both species but its structure was not identified.

CuBr2 mediated synthesis of 2-Aminothiazoles from dithiocarbamic acid salts and ketones

In a one-pot procedure, CuBr2 has been used as a efficient desulfurizing agent in the synthesis of 2-aminothiazoles by the condensation of in situ-generated 1-substituted thioureas from their dithiocarbamic acid salts, with in situ-generated α-bromoketones from ketones. All reactions were carried out under optimized reaction conditions and gave the target products in 61–95% yield.

Design, synthesis and biological evaluation of novel HSP70 inhibitors: N, N′-disubstituted thiourea derivatives

As novel heat shock protein 70 (HSP70) inhibitors, N, N′-disubstituted thiourea derivatives were designed and synthesized based on the X-ray structure of the ATPase domain (nucleotide binding domain, NBD). An ATPase activity inhibition assay revealed that these compounds effectively inhibited HSP70 ATPase activity. The results revealed that the compounds 370/371/374/379/380//392/394/397/404/405 and 407 can inhibit the HSP70 ATPase turnover with high percentages of inhibition: 50.42, 38.46, 50.45, 44.12, 47.13, 50.50, 40.95, 65.36, 46.23, 35.78, and 58.37 in 200 μM, respectively. Significant synergies with lapatinib were observed for compound 379 and compound 405 in the BT474 breast cancer cell line. A structure-function analysis revealed that most of the thiourea derivatives exhibited cooperative action with lapatinib in the BT474 cancer cell line and the BT/LapR1.0 lapatinib-resistant cell line. HSP70 inhibitors may be developed as synergetic drugs in drug-resistant cancer therapy.