143026-79-3

Basic information

• Product Name: Oxazole, 2-(dichloromethyl)-4-(fluoromethyl)-4,5-dihydro-5-[4-(methylsulfonyl)phe nyl]-, (4S-trans)-
• CAS NO: 143026-79-3
• Molecular Formula: C12H12Cl2FNO3S
• Molecular Weight: 340.203
• Mol File: 143026-79-3.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Oxazole, 2-(dichloromethyl)-4-(fluoromethyl)-4,5-dihydro-5-[4-(methylsulfonyl)phe nyl]-, (4S-trans)-(CAS DataBase Reference)
• NIST Chemistry Reference: Oxazole, 2-(dichloromethyl)-4-(fluoromethyl)-4,5-dihydro-5-[4-(methylsulfonyl)phe nyl]-, (4S-trans)-(143026-79-3)
• EPA Substance Registry System: Oxazole, 2-(dichloromethyl)-4-(fluoromethyl)-4,5-dihydro-5-[4-(methylsulfonyl)phe nyl]-, (4S-trans)-(143026-79-3)

Safety Data

• Hazardous Substances Data: 143026-79-3(Hazardous Substances Data)

Upstream product

• 31925-29-8 (2S,3R)-2-amino-3-hydroxy-3-(4-methylsulfonylphenyl)propionic acid ethyl ester 
• 100-68-5 methyl-phenyl-thioether 
• 90919-11-2 β-chloroethyl p-methylthiophenyl ketone 
• 701935-64-0 1-[4-(methylsulfanyl)phenyl]-2-propen-1-ol 
• 125872-62-0 (E)-3-[4-(methylsulfanyl)phenyl]prop-2-en-1-ol 
• 3446-89-7 4-(Methylthio)benzaldehyde 
• 1338046-00-6 (R)-((R)-3-benzyl-2-oxooxazolidin-4-yl)[4-(methylsulfonyl)phenyl]methyl acetate 
• 1338045-99-0 (R)-3-benzyl-4-[(S)-hydroxy(4-methylsulfonylphenyl)methyl]oxazolidin-2-one 

Downstream Products

• 73231-34-2 Florfenicol 

Relevant articles and documents

METHODS FOR PREPARING FLORFENIOL AND INTERMEDIATE THEREOF

The present invention discloses a method for preparing florfenicol and its intermediate (V), comprising an addition reaction, a ring closure reaction, a hydrolysis reaction, a ring opening reaction, a reduction reaction, a ring reaction, a fluorination reaction and a ring opening reaction. In the present method for preparing florfenicol, respective reaction steps can be continuously operated, therefore the methods of the present invention features simplified process and shorter synthetic route, and obtained florfenicol has high chiral purity and is of high yield. The method of the present invention for preparing florfenicol (TM) using the intermediate (V) avoids waste water pollution and reduces the cost for treating wastewater and alleviates environmental pollution. At the same time, the methods of the present invention eliminates a chiral resolution procedure, thus increasing the utilization rate of atoms in the reaction. As a result, cost is reduced and process is simplified.

Synthesis method of florfenicol

The invention discloses a synthesis method of florfenicol, which comprises the following steps: by using (4R,5R)-2-dichloromethyl-4,5-dihydro-5-[4-(methylsulfonyl)phenyl]-4-oxazolemethanol (compound Ifor short) as a reaction raw material, carrying out chlorination, fluorination and hydrolysis to obtain florfenicol. The method has the advantages of cheap and easily available raw materials, simpleprocess operation, environmental protection and no pollution, accords with the industrialization concept of green production, and has extremely high industrialization value.

Florfenicol intermediate state compound and method for preparing florfenicol intermediate

Shows-dihydro - 5-dihydro,5-(methylsulfonyl phenyl oxazoline) in the preparation good reagent to, obtain florfenicol intermediate by performing fluoro- reaction (4R,5R) - 2 - on-dichloro-methyl) - 4) 4-(methylsulfonyl ishikawa),intermediate compound, in, a microchannel reaction system to prepare a fluorobenzil intermediate, in a microchannel reactor ; The reaction container, is, prepared by the 130-160 °C, 1.6-2.0Mpa method of, the present invention. The method for preparing florfenicol intermediate, is shown in the present invention in a microchannel, reactor at a temperature of, ?0.0.0.60.0.60.0.60.60.0.60.60.60.60.60.60.60.60.60.60.60.60.6.