1430270-75-9Relevant academic research and scientific papers
One-pot synthesis of 5-oxopyrrolidine-2-carboxamides via a tandem Ugi 4CC/SN cyclization starting from Baylis-Hillman bromides
Zeng, Xiao-Hua,Wang, Hong-Mei,Wu, Lei,Ding, Ming-Wu
, p. 3823 - 3828 (2013)
A one-pot base-mediated synthesis of 5-oxopyrrolidine-2-carboxamides was developed. The reaction of Baylis-Hillman bromides 1, primary amines 2, isocyanides 3 and arylglyoxals 4 produced the 5-oxopyrrolidine-2-carboxamides 6 in good yields via a tandem Ugi condensation and intramolecular substitution at room temperature in the presence of Cs2CO3.
