1430413-87-8

Basic information

• Product Name: 2-((benzyloxy)carbonyl)-3-methylbutanoic acid
• Synonyms: 2-((benzyloxy)carbonyl)-3-methylbutanoic acid
• CAS NO: 1430413-87-8
• Molecular Weight: 236.268
• Mol File: 1430413-87-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-((benzyloxy)carbonyl)-3-methylbutanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-((benzyloxy)carbonyl)-3-methylbutanoic acid(1430413-87-8)
• EPA Substance Registry System: 2-((benzyloxy)carbonyl)-3-methylbutanoic acid(1430413-87-8)

Safety Data

• Hazardous Substances Data: 1430413-87-8(Hazardous Substances Data)

Upstream product

• 124-38-9 carbon dioxide 
• 103-38-8 benzyl isovalerate 
• 601-79-6 isopropylmalonic acid 
• 100-51-6 benzyl alcohol 

Relevant articles and documents

Diastereoselective anodic hetero- and homo-coupling of menthol-, 8-methylmenthol- and 8-phenylmenthol-2-alkylmalonates

Diastereoselective radical coupling was achieved with chiral auxiliaries. The radicals were generated by anodic decarboxylation of five malonic acid derivatives. These were prepared from benzyl malonates and four menthol auxiliaries. Coelectrolyses with 3,3-dimethylbutanoic acid in methanol at platinum electrodes in an undivided cell afforded hetero-coupling products in 22-69% yield with a diastereoselectivity ranging from 5 to 65% de. Electrolyses without a coacid led to diastereomeric homo-coupling products in 21-50% yield with ratios of diastereomers being 1.17:2.00:0.81 to 7.03:2.00. The stereochemistry of the new stereogenic centers was confirmed by X-ray structure analysis and 13C NMR data.

VEGF NEUTRALIZING PRODRUGS FOR THE TREATMENT OF OCULAR CONDITIONS

The present invention relates to a pharmaceutical composition comprising one or more pharmaceutically acceptable excipient(s) and a VEGF neutralizing prodrug, which comprises a VEGF neutralizing biologically active moiety, for use in a method for the treatment of one or more ocular conditions.