1430419-39-8

Basic information

• Product Name: 2,3-bis(2-fluoro-4-hydroxyphenyl)thiophene
• Synonyms: 2,3-bis(2-fluoro-4-hydroxyphenyl)thiophene
• CAS NO: 1430419-39-8
• Molecular Weight: 304.317
• Mol File: 1430419-39-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,3-bis(2-fluoro-4-hydroxyphenyl)thiophene(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-bis(2-fluoro-4-hydroxyphenyl)thiophene(1430419-39-8)
• EPA Substance Registry System: 2,3-bis(2-fluoro-4-hydroxyphenyl)thiophene(1430419-39-8)

Safety Data

• Hazardous Substances Data: 1430419-39-8(Hazardous Substances Data)

Upstream product

• 1430419-37-6 2,3-bis(2-fluoro-4-methoxyphenyl)thiophene 
• 162101-31-7 (2-fluoro-4-methoxyphenyl)boronic acid 

Relevant articles and documents

Thiophene-core estrogen receptor ligands having superagonist activity

To probe the importance of the heterocyclic core of estrogen receptor (ER) ligands, we prepared a series of thiophene-core ligands by Suzuki cross-coupling of aryl boronic acids with bromo-thiophenes and we assessed their receptor binding and cell biological activities. The disposition of the phenol substituents on the thiophene core, at alternate or adjacent sites, and the nature of substituents on these phenols, all contribute to binding affinity and subtype selectivity. Most of the bis(hydroxyphenyl)-thiophenes were ERβ selective, whereas the tris(hydroxyphenyl)-thiophenes were ERα selective; analogous furan-core compounds generally have lower affinity and less selectivity. Some diarylthiophenes show distinct superagonist activity in reporter gene assays, giving maximal activities 2-3 times that of estradiol, and modeling suggests that these ligands have a different interaction with a hydrogen-bonding residue in helix-11. Ligand-core modification may be a new strategy for developing ER ligands whose selectivity is based on having transcriptional activity greater than that of estradiol.